Abstract
4/2020
vol. 36
Review paper
Colorectal cancer in the course of familial adenomatous polyposis: natural history and treatment methods
- Department of Surgical Medicine with the Laboratory of Medical Genetics, Institute of Medical Sciences, Jan Kochanowski University, Kielce, Poland
- Department of Clinic General Oncological and Endocrinological Surgery, Regional Hospital, Kielce, Poland
- Department of Surgical Oncology, Holy Cross Cancer Center, Kielce, Poland
- Collegium Medicum, Jan Kochanowski University, Kielce, Poland
Medical Studies/Studia Medyczne 2020; 36 (4): 303–309
Online publish date: 2020/12/31
Familial adenomatous polyposis (FAP) is a group of diseases, mostly caused by an APC suppressor gene mutation inherited in an autosomal dominant pattern. It results in numerous adenomas formed in the epithelium of the large intestine leading to colorectal cancer in 100% of cases, with the mean age of 39, and a high risk of other fatal neoplasms. There is no causative treatment possible. Total colectomy performed at the right time is the only way to prevent the individual from developing colorectal cancer. The aim of this study was to present the diagnostic performance and treatment methods of FAP. Fast diagnosis and strict surveillance of patients and their families are the most important for effective treatment.
Keywords
colorectal cancer, familial adenomatous polyposis, familial polyposis coli, APC gene mutation
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