Role of microRNA in pathogenesis, diagnostics and therapy  of cancer

Karolina Majorek; Włodzimierz J. Krzyżosiak

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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8/2006
vol. 10

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abstract:

Role of microRNA in pathogenesis, diagnostics and therapy of cancer

Karolina Majorek

,

Włodzimierz J. Krzyżosiak

Współcz Onkol (2006) vol. 10; 8 (359–366)

Online publish date: 2006/10/16

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This article presents in brief some basic facts regarding biogenesis and physiological function of microRNAs, which are potent regulators of cell proliferation, differentiation, apoptosis, embryogenesis and organogenesis. The recently revealed links between microRNA dysfunction and human cancers are more extensively discussed, and some examples and perspectives of microRNA application in diagnostics, prognostics and therapy of cancer are presented. The postulated connection between germline mutations in microRNA genes and predisposition to cancer is also discussed.

keywords:

Role of microRNA in pathogenesis, diagnostics and therapy of cancer

Karolina Majorek , Włodzimierz J. Krzyżosiak

microRNA biogenesis, microRNA function, microRNA expression profiles, microRNAs as oncogenes, microRNAs as tumour suppressors

Karolina Majorek

,

Włodzimierz J. Krzyżosiak