Abstract
2/2000
vol. 4
Role of the neoadjuvant therapy in the treatment of advanced carcinoma of the esophagus
Współcz Onkol (2000) vol. 4, 2 (80-83)
Online publish date: 2003/07/25
The aim of this study was to compare microscopically radical resection (R0) rate after surgery alone, preoperative chemotherapy, and preoperative chemo-/radiotherapy.
Between 1992-1997, 101 patients were operated for squamous cell carcinoma of the esophagus. Thirty four patients were treated by surgery alone, in 42 patients surgery followed preoperative chemotherapy with cisplatin (20 mg/m2/dobe; days: 1-5 i 17-21 days) and 5-FU (300 mg/m2/dobe; for 21 days). In 25 patients concurrently with chemotherapy, radiotherapy was applied in fractions (for 15 days) up to total dose of 3000 cGy. Postoperative mortality and morbidity was 15% and 50%, respectively. In the chemotherapy group, complete response (CR) rate was 4,8%, partial response (PR) was 80,9%, and stabile disease (SD) was observed in 14,3% of patients. In the chemo-/radiotherapy group the CR, PR, and SD rate were 8%, 80%, and 12%, respectively. The R0 resection rates after surgery alone, preoperative chemotherapy and chemo-/radiotherapy were 3%, 26%, and 40%, respectively.
Conclusion: in patients with advanced squamous cell carcinoma of the esophagus, preoperative chemo- and/or radiotherapy improves microscopically radical resection rate, as compared to surgery alone.
Between 1992-1997, 101 patients were operated for squamous cell carcinoma of the esophagus. Thirty four patients were treated by surgery alone, in 42 patients surgery followed preoperative chemotherapy with cisplatin (20 mg/m2/dobe; days: 1-5 i 17-21 days) and 5-FU (300 mg/m2/dobe; for 21 days). In 25 patients concurrently with chemotherapy, radiotherapy was applied in fractions (for 15 days) up to total dose of 3000 cGy. Postoperative mortality and morbidity was 15% and 50%, respectively. In the chemotherapy group, complete response (CR) rate was 4,8%, partial response (PR) was 80,9%, and stabile disease (SD) was observed in 14,3% of patients. In the chemo-/radiotherapy group the CR, PR, and SD rate were 8%, 80%, and 12%, respectively. The R0 resection rates after surgery alone, preoperative chemotherapy and chemo-/radiotherapy were 3%, 26%, and 40%, respectively.
Conclusion: in patients with advanced squamous cell carcinoma of the esophagus, preoperative chemo- and/or radiotherapy improves microscopically radical resection rate, as compared to surgery alone.
Keywords
squamous cell carcinoma of the esophagus, neoadjuvant treatment, chemotherapy, radiotherapy, surgery
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