Severe adenomyosis with unexpectedly high CA-125: report of a rare case

Ibrahim Abdelazim; Mohannad AbuFaza; Mohamed E.S. Hamed; Yerbol Bekmukhambetov; Gulmira Zhurabekova; Svetlana Shikanova

doi:10.5114/pm.2020.99610

eISSN: 2299-0038
ISSN: 1643-8876

Menopause Review/Przegląd Menopauzalny

Current issue Archive Online First About the journal Editorial board Abstracting and indexing Subscription Contact Ethical standards and procedures Special Issues Instructions for authors Publication charge

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

3/2020
vol. 19

Send email

Copy url:

abstract:

Case report

Severe adenomyosis with unexpectedly high CA-125: report of a rare case

Ibrahim A. Abdelazim

^{1, 2}

,

Mohannad AbuFaza

²

,

Mohamed E.S. Hamed

¹

,

Yerbol Bekmukhambetov

³

,

Gulmira Zhurabekova

⁴

,

Svetlana Shikanova

⁵

Department of Obstetrics and Gynecology, Ain Shams University, Cairo, Egypt
Department of Obstetrics and Gynecology, Ahmadi Kuwait Oil (KOC) Company Hospital, Ahmadi, Kuwait
Department of Oncology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Normal and Topographic Anatomy, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Obstetrics and Gynecology No. 1, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan

Menopause Rev 2020; 19(3): 144-146

DOI: https://doi.org/10.5114/pm.2020.99610

Online publish date: 2020/10/02

View full text Get citation

PlumX metrics:

A 46-year-old woman presented to the emergency department with abdominal pain and abnormal uterine bleeding over the last year. She had a history of failed cyclic progesterone with tranexamic acid over the last 3 months to control her bleeding attacks. She had a tender pelvi-abdominal mass of 28 weeks’ gestation size. Therapeutic curettage was performed, followed by correction of her iron deficiency anemia with intravenous iron.

The trans-abdominal ultrasound of the pelvi-abdominal mass showed asymmetrical myometrial thickening, predominantly its anterior wall, with myometrial hyperechoic regions surrounded by hypoechoic areas suggestive of adenomyosis uterus for magnetic resonance imaging (MRI) evaluation.

The MRI evaluation confirmed the diagnosis of adenomyosis uterus and showed diffuse asymmetrical uterine adenomyosis, predominantly its anterior myometrial wall, with an ill-defined endo-myometrial junction. Total abdominal hysterectomy with bilateral salpingectomy and bilateral ovarian conservation was performed after departmental approval and the patient’s consent.

The routine pre-operative investigations were completely normal except the cancer antigen (CA-125) which was unexpectedly high (1658 and 1046 IU/ml repeated twice two days apart). The histological examination of the surgical removed uterus confirmed the diagnosis of adenomyosis uterus and the pre-operative high CA-125 decreased to 22 IU/ml (normal range 0-35 IU/ml) one week after surgery.

Conclusions: Unexpectedly high CA-125 over 1000 IU/ml can be seen in benign gynecologic conditions such as severe adenomyosis. The high CA-125 level is positively correlated to the uterine size in severe adenomyosis.

keywords:

Severe adenomyosis with unexpectedly high CA-125: report of a rare case

Ibrahim A. Abdelazim 1, 2 , Mohannad AbuFaza 2 , Mohamed E.S. Hamed 1 , Yerbol Bekmukhambetov 3 , Gulmira Zhurabekova 4 , Svetlana Shikanova 5

severe, adenomyosis, high, CA-125, report

Ibrahim A. Abdelazim

^{1, 2}

,

Mohannad AbuFaza

²

,

Mohamed E.S. Hamed

¹

,

Yerbol Bekmukhambetov

³

,

Gulmira Zhurabekova

⁴

,

Svetlana Shikanova

⁵