Aim of the study. To create a statistical and prognostic
model of caries formation and progression in children
of preschool and early school age domiciled in
biogeochemical deficiency of fluorine and iodine.
Materials and methods. Microbial landscape
was identified with biochemical parameters and
immunological status of saliva in 146 children
aged 3-8 years of different ethnic groups. Statistical
evaluation of the results was conducted. Conclusions.
For the formation and progression of caries the
presence of Str. sobrinus is necessary plus dysbiotic
changes in the oral cavity (decrease of concentrations
of Bifidobacterium and Lactobacillus salivarius,
emergence of conditionally pathogenic and pathogenic
microorganisms), increasing concentration of ionized
calcium, alkaline phosphatase, and lower levels of
phosphorus and pH.