Przegląd Menopauzalny

Abstract

3/2022 vol. 21
Original paper

The influence of advanced age and obesity on pregnancy course and outcome in patients with diabetes mellitus

  1. Clinical Academic Department of Women’s Health, Corporate Fund “University Medical Centre”, Nur-Sultan, Kazakhstan
  2. Department of Medicine, School of Medicine, Nazarbayev University, Nur-Sultan, Kazakhstan
  3. Clinic of Obstetrics and Gynaecology, Clinical Centre of Serbia, Belgrade, Serbia
  4. School of Medicine, University of Belgrade, Belgrade, Serbia
  5. Department of Obstetrics and Gynaecology, Faculty of Medicine, Van Yüzüncü Yıl University, Van, Turkey
  6. Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
  7. Unit of Gynecologic Oncology, ARNAS "Civico – Di Cristina – Benfratelli", Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy
Menopause Rev 2022; 21(3): 170-179
Online publish date: 2022/05/18
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Introduction

Older women are at greater risk of suffering from a series of comorbidities such as obesity, diabetes, and hypertension that could negatively affect pregnancy course and outcomes. This study aims to investigate the impact of maternal age and pre-pregnancy body mass index (BMI) on pregnancy outcomes of women with diabetes mellitus (DM).

Material and methods

The study included 323 diabetic pregnant women. All complications throughout pregnancy and the early neonatal period were noted. The women were divided into groups according to age decade and BMI.

Results

84.8% of women reported pregnancy complications, with a higher prevalence in obese women (p = 0.003). However, most children had a good outcome with few early neonatal complications (36.85%). Old and obese women with DM often showed complications, and their newborns had higher birth weight (p = 0.003) and more neonatal complications (p = 0.041). Maternal BMI (p = 0.016; OR = 1.064), but not age (p = 0.801), was found to be a significant predictor of pregnancy complications.

Conclusions

Pregnant women with DM should be considered as high-risk patients. Advanced age and increased BMI prior to pregnancy are risk factors for pregnancy complications. Maternal obesity is the most important predictor of pregnancy complications in women with DM. Pregnancy outcome can be good for both mothers and children with a timely and adequate approach.

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