Menopause Review
facebook
eISSN: 2299-0038
ISSN: 1643-8876
Menopause Review/Przegląd Menopauzalny
Current issue Archive Online First About the journal Editorial board Editorial office Publisher Abstracting and indexing Subscription Contact Ethical standards and procedures Special Issues Instructions for authors Publication charge
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank


Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

without publication fees
1/2024
vol. 23
 
Share:
Send email
Share:
abstract:
Original paper

The relationship between vitamin D and adolescents’ parathyroid hormone and bone mineral density

Ainur Donayeva
1
,
Ainur Amanzholkyzy
1
,
Ibrahim A. Abdelazim
2
,
Saule Rakhyzhanova
3
,
Akzhunus Mannapova
4
,
Talgar Abilov
1
,
Zaituna Khamidullina
5
,
Karlygash Bimagambetova
1
,
Gulnara Gubasheva
6
,
Dinara Kulzhanova
1
,
Akbayan Turesheva
1
,
Samat Saparbayev
1

  1. Department of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
  2. Department of Obstetrics and Gynaecology, Faculty of Medicine Ain Shams University, Cairo, Egypt
  3. Department of Physiological Disciplines, Named after T.A. Nazarova, NCJSC, Semey Medical University, Semey, Kazakhstan
  4. Department of Neurology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
  5. Department of Obstetrics and Gynaecology №1, Astana Medical University, Astana, Kazakhstan
  6. Department of Obstetrics and Gynaecology №2, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Menopause Rev 2024; 23(1): 1-5
DOI: https://doi.org/10.5114/pm.2024.136327
Online publish date: 2024/03/17
View full text Get citation
 
PlumX metrics:
Introduction
To detect the relationship between 25-hydroxy vitamin D (25(OH)D) and adolescents’ parathyroid hormone (PTH) and bone mineral density (BMD).

Material and methods
Two hundred adolescent girls were recruited for this cross-sectional comparative study. After detailed evaluation, a pelvic sonography was performed for the studied adolescents to rule out any pelvic pathology. Adolescents’ blood samples were collected to measure the thyroid stimulating hormone, prolactin, glycosylated haemoglobin (HbA1C), PTH, and 25(OH)D. The studied adolescents’ BMD and the T-score were evaluated at 2 anatomical sites. The studied adolescents were classified according to their serum 25(OH)D into 2 groups: a 25(OH)D-deficient group (study group; 25(OH)D < 20 ng/ml) and normal controls (25(OH)D > 30 ng/ml). Student’s t-test was used for analysis of the studied adolescents’ variables, and correlation analysis (Pearson`s correlation) was used to detect the relationship between 25(OH)D and adolescents’ PTH and BMD.

Results
The parathyroid hormone was statistically higher in the 25(OH)D-deficient group than in the normal controls (41.3 ±3.4 pg/ml vs. 21.1 ±2.8) (p = 0.02), and the BMD was statistically lower in the 25(OH)D-deficient group than in the normal controls (–1.25 ±0.5 vs. 0.3 ±0.4) (p = 0.01). The 25(OH)D had a significant negative correlation with the adolescents’ PTH (r = –0.9175; p < 0.00001) and a significant positive correlation with the adolescents’ BMD (r = 0.756; p < 0.00001). The parathyroid hormone had a significant negative correlation with the adolescents’ BMD (r = –0.7006; p < 0.00001).

Conclusions
The parathyroid hormone in this study had significant negative correlations with both 25(OH)D and BMD. The 25(OH)D had a significant positive correlation with the studied adolescents’ BMD.

keywords:

bone mineral density, parathyroid hormone, vitamin D

Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2026 Termedia Sp. z o.o.
Developed by Termedia.