Three cases of dual diagnosis: paranoid schizophrenia and cannabis use disorder – case studies and literature review

Jerzy Samochowiec

doi:10.5114/psychs.2025.153197

ISSN: 2720-7048

Psychiatria Spersonalizowana / Personalized Psychiatry

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1/2025
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abstract:

Case report

Three cases of dual diagnosis: paranoid schizophrenia and cannabis use disorder – case studies and literature review

Jerzy Samochowiec

¹

Katedra i Klinika Psychiatrii Pomorskiego Uniwersytetu Medycznego w Szczecinie; Department and Clinic of Psychiatry, Pomeranian Medical University in Szczecin

Personalized Psychiatry 2025; 4: e71–e75

DOI: https://doi.org/10.5114/psychs.2025.153197

Online publish date: 2025/08/04

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This article presents three clinical cases of patients diagnosed with paranoid schizophrenia (F20.0) and co-occurring cannabis dependence syndrome (F12.2), along with a review of published case reports on the use of cariprazine in similar populations. Patients had previously received various antipsychotics with limited success. Switching to cariprazine led to improvements in positive and negative symptoms, and social functioning. The article includes a discussion of cariprazine’s D3-related mechanisms and presents data from case reports and observational studies. The need for individualized treatment and integration of psychiatric and addiction care is emphasized.

keywords:

Three cases of dual diagnosis: paranoid schizophrenia and cannabis use disorder – case studies and literature review

Jerzy Samochowiec 1

paranoid schizophrenia, cannabis, dual diagnosis, cariprazine, clinical case

Jerzy Samochowiec

¹