Among all complaints, pain is one of the most frequently reported symptoms and reasons for using cannabinoids. Adding them to the ongoing treatment of chronic pain is usually a step when standard treatment with analgesics and coanalgesics does not provide satisfactory clinical results or drugs cause unacceptable side effects. Sometimes patients themselves take such a suggestion into consideration. When initiating therapy with cannabinoids, particularly with THC-containing preparations, basic and simple principles should be followed each time. The article presents recommendations developed and based on expert consensus using a modified Delphi process on how to dose and administer cannabinoids in the treatment of patients with chronic pain. CBD and/or THC should be introduced into therapy according to the well-known “start low, go slow” principle. Proper education regarding the use of THC in the form of extracts, as well as communication with the patient, can be of key importance in the attitude towards such therapy, which often translates into its success. Adequate follow-up during titration and continuation of the therapy will ensure patient comfort and safety.