Experimental immunology 
The effect of Rhodiola kirilowii extracts on pigs’ blood leukocytes metabolic (RBA) and proliferative (LPS) activity, and on the bacterial infection and blood leukocytes number in mice

Andrzej K. Siwicki; Ewa Skopińska-Różewska; Aleksander Wasiutyński; Roman Wójcik; Robert Zdanowski; Ewa Sommer; Waldemar Buchwald; Mirosława Furmanowa; Tadeusz Bakuła; Wanda Stankiewicz

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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2/2012
vol. 37

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abstract:

Experimental immunology
The effect of Rhodiola kirilowii extracts on pigs’ blood leukocytes metabolic (RBA) and proliferative (LPS) activity, and on the bacterial infection and blood leukocytes number in mice

Andrzej K. Siwicki

,

Ewa Skopińska-Różewska

,

Aleksander Wasiutyński

,

Roman Wójcik

,

Robert Zdanowski

,

Ewa Sommer

,

Waldemar Buchwald

,

Mirosława Furmanowa

,

Tadeusz Bakuła

,

Wanda Stankiewicz

(Centr Eur J Immunol 2012; 37 (2): 145-150)

Online publish date: 2012/05/22

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AMA

Siwicki A, Skopińska-Różewska E, Wasiutyński A, et al. Experimental immunology
The effect of Rhodiola kirilowii extracts on pigs’ blood leukocytes metabolic (RBA) and proliferative (LPS) activity, and on the bacterial infection and blood leukocytes number in mice. Central European Journal of Immunology. 2012;37(2):145-150.

APA

Siwicki, A., Skopińska-Różewska, E., Wasiutyński, A., Wójcik, R., Zdanowski, R.,  & Sommer, E. et al. (2012). Experimental immunology
The effect of Rhodiola kirilowii extracts on pigs’ blood leukocytes metabolic (RBA) and proliferative (LPS) activity, and on the bacterial infection and blood leukocytes number in mice. Central European Journal of Immunology, 37(2), 145-150.

Chicago

Siwicki, Andrzej K., Ewa Skopińska-Różewska, Aleksander Wasiutyński, Roman Wójcik, Robert Zdanowski, Ewa Sommer,  and Waldemar Buchwald et al. 2012. "Experimental immunology
The effect of Rhodiola kirilowii extracts on pigs’ blood leukocytes metabolic (RBA) and proliferative (LPS) activity, and on the bacterial infection and blood leukocytes number in mice". Central European Journal of Immunology 37 (2): 145-150.

Harvard

Siwicki, A., Skopińska-Różewska, E., Wasiutyński, A., Wójcik, R., Zdanowski, R., Sommer, E., Buchwald, W., Furmanowa, M., Bakuła, T.,  and Stankiewicz, W. (2012). Experimental immunology
The effect of Rhodiola kirilowii extracts on pigs’ blood leukocytes metabolic (RBA) and proliferative (LPS) activity, and on the bacterial infection and blood leukocytes number in mice. Central European Journal of Immunology, 37(2), pp.145-150.

MLA

Siwicki, Andrzej K. et al. "Experimental immunology
The effect of Rhodiola kirilowii extracts on pigs’ blood leukocytes metabolic (RBA) and proliferative (LPS) activity, and on the bacterial infection and blood leukocytes number in mice." Central European Journal of Immunology, vol. 37, no. 2, 2012, pp. 145-150.

Vancouver

Siwicki A, Skopińska-Różewska E, Wasiutyński A, Wójcik R, Zdanowski R, Sommer E et al. Experimental immunology
The effect of Rhodiola kirilowii extracts on pigs’ blood leukocytes metabolic (RBA) and proliferative (LPS) activity, and on the bacterial infection and blood leukocytes number in mice. Central European Journal of Immunology. 2012;37(2):145-150.

Rhodiola kirilowii roots and rhizomes extracts are used in Asiatic medicine independently of their adaptogenic properties also as antimicrobial and anti-inflammatory drugs. The aim of this work was to study the in vitro modulatory potential of aqueous and hydro-alcoholic extracts of under-ground parts of Rhodiola kirilowii (RK) on respiratory burst activity (RBA) and on the proliferative response to lipopolysaccharide (LPS) in blood leukocyte cultures of pigs. Both extracts in concentration up to 10 µg/ml stimulated this parameter. Higher concentrations of RK extracts were ineffective (20 µg/ml) or inhibitory (50 µg/ml).

Further, the effect of feeding mice with Rhodiola kirilowi aqueous (RKW) and 50% hydro-alcoholic (RKA) extracts on Pseudomonas aeruginosa infection was studied. It was found that the infection intensity was significantly lower, in comparison to the control, when mice obtained daily, for 7 days before P. aeruginosa i.p. inoculation, 0.4 mg of RKA or RKW extract. Accordingly, feeding mice with both extracts for 7 days, in 0.1 and 0.2 mg (RKW) and 0.1 mg (RKA) daily doses, increased blood leukocytes (both lymphocytes and granulocytes) number.

keywords:

Experimental immunology The effect of Rhodiola kirilowii extracts on pigs’ blood leukocytes metabolic (RBA) and proliferative (LPS) activity, and on the bacterial infection and blood leukocytes number in mice

Andrzej K. Siwicki , Ewa Skopińska-Różewska , Aleksander Wasiutyński , Roman Wójcik , Robert Zdanowski , Ewa Sommer , Waldemar Buchwald , Mirosława Furmanowa , Tadeusz Bakuła , Wanda Stankiewicz

Rhodiola kirilowii, mice, pigs, leukocytes, RBA, LPS, bacterial infection

Experimental immunology
The effect of Rhodiola kirilowii extracts on pigs’ blood leukocytes metabolic (RBA) and proliferative (LPS) activity, and on the bacterial infection and blood leukocytes number in mice

Andrzej K. Siwicki

,

Ewa Skopińska-Różewska

,

Aleksander Wasiutyński

,

Roman Wójcik

,

Robert Zdanowski

,

Ewa Sommer

,

Waldemar Buchwald

,

Mirosława Furmanowa

,

Tadeusz Bakuła

,

Wanda Stankiewicz