eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
5/2014
vol. 9
 
Share:
Share:
abstract:
Review paper

Alterations in programmed cell death mechanism and their role in the pathogenesis of inflammatory bowel diseases

Piotr Eder
,
Liliana Łykowska-Szuber
,
Kamila Stawczyk-Eder
,
Iwona Krela-Kaźmierczak
,
Krzysztof Linke

Prz Gastroenterol 2014; 9 (5): 275–279
Online publish date: 2014/10/19
View full text Get citation
 
PlumX metrics:
Apoptosis plays an essential role in both physiology and pathology. In the pathogenesis of inflammatory bowel diseases, disturbances of apoptosis also play an important role. Inflammatory cells (for example lymphocytes, granulocytes) in the gut wall are resistant to apoptotic stimuli and they accumulate there causing tissue damage. On the other hand, apoptotic elimination of the enterocytes is enhanced, which leads to the impairment of the gut barrier. The exact mechanisms of these phenomena are still poorly understood and they are still under investigation. The present paper summarises current knowledge in terms of the role of alterations of programmed cell death in the pathogenesis of inflammatory bowel diseases.
keywords:

inflammatory bowel diseases, apoptosis, lymphocytes, enterocytes

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.