Aspects of use of selected metal complexes in anti-cancer therapy

Tomasz Dąbrowski

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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6/1999
vol. 3

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abstract:

Aspects of use of selected metal complexes in anti-cancer therapy

Tomasz Dąbrowski

Współcz Onkol (1999) 6, 249-252

Online publish date: 2003/08/07

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The anti-cancer properties and clinical usefulness of cisplatin and its derivatives indicated a need of searching for other metal complexes of similar activities. Anti-cancer activity was proved for complexes of titanium (IV), germanium (IV), gallium (III), ruthenium (III), palladium (II) and tin (IV). Only the first three of them favourably passed I/II phase of clinical trials.

In this article the actual state of knowledge about mechanisms of activity of several titanium, germanium and gallium complexes, profiles of their anti-cancer activity observed in in vivo and in vitro laboratory investigations as well as conducted clinical trials are presented.

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Aspects of use of selected metal complexes in anti-cancer therapy

Tomasz Dąbrowski

ati-cancer metal complexes, cytotoxicity