Assessment of insulin resistance in preterm children appropriate for gestational age versus term and preterm children with intrauterine growth restriction

Alicja Korpysz; Marta Wysocka-Mincewicz; Mieczysław Szalecki

doi:10.5114/pedm.2021.109128

eISSN: 2083-8441
ISSN: 2081-237X

Pediatric Endocrinology Diabetes and Metabolism

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abstract:

Original paper

Assessment of insulin resistance in preterm children appropriate for gestational age versus term and preterm children with intrauterine growth restriction

Alicja Korpysz

¹

,

Marta Wysocka-Mincewicz

¹

,

Mieczysław Szalecki

¹

Department of Endocrinology and Diabetology, The Children’s Memorial Health Institute, Warsaw, Poland

Pediatr Endocrinol Diabetes Metab 2021; 27 (4): 249–252

DOI: https://doi.org/10.5114/pedm.2021.109128

Online publish date: 2021/12/30

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AMA

Korpysz A, Wysocka-Mincewicz M, Szalecki M. Assessment of insulin resistance in preterm children appropriate for gestational age versus term and preterm children with intrauterine growth restriction. Pediatric Endocrinology Diabetes and Metabolism. 2021;27(4):249-252. doi:10.5114/pedm.2021.109128.

APA

Korpysz, A., Wysocka-Mincewicz, M.,  & Szalecki, M. (2021). Assessment of insulin resistance in preterm children appropriate for gestational age versus term and preterm children with intrauterine growth restriction. Pediatric Endocrinology Diabetes and Metabolism, 27(4), 249-252. https://doi.org/10.5114/pedm.2021.109128

Chicago

Korpysz, Alicja, Marta Wysocka-Mincewicz,  and Mieczysław Szalecki. 2021. "Assessment of insulin resistance in preterm children appropriate for gestational age versus term and preterm children with intrauterine growth restriction". Pediatric Endocrinology Diabetes and Metabolism 27 (4): 249-252. doi:10.5114/pedm.2021.109128.

Harvard

Korpysz, A., Wysocka-Mincewicz, M.,  and Szalecki, M. (2021). Assessment of insulin resistance in preterm children appropriate for gestational age versus term and preterm children with intrauterine growth restriction. Pediatric Endocrinology Diabetes and Metabolism, 27(4), pp.249-252. https://doi.org/10.5114/pedm.2021.109128

MLA

Korpysz, Alicja et al. "Assessment of insulin resistance in preterm children appropriate for gestational age versus term and preterm children with intrauterine growth restriction." Pediatric Endocrinology Diabetes and Metabolism, vol. 27, no. 4, 2021, pp. 249-252. doi:10.5114/pedm.2021.109128.

Vancouver

Korpysz A, Wysocka-Mincewicz M, Szalecki M. Assessment of insulin resistance in preterm children appropriate for gestational age versus term and preterm children with intrauterine growth restriction. Pediatric Endocrinology Diabetes and Metabolism. 2021;27(4):249-252. doi:10.5114/pedm.2021.109128.

PlumX metrics:

Introduction
Estimation of carbohydrate metabolism parameters in the groups: AGA preterm, SGA term, SGA preterm and AGA term.

Material and methods
89 children were qualified: group A – AGA preterm 22, group B – SGA preterm 26, SGA term group C – 30 children, AGA – term group D – 11 children; at the age of 6–7 years. Insulin and fasting glucose levels were measure. HOMA IR and QUICKI, lipid profile were calculated.

Results
Higher insulin concentration were found in groups C vs. A (6.93 vs. 3.68 uIU/ml, p = 0.00005); B vs A (5.49 vs. 3.68 uIU/ml, p = 0.02). HOMA IR was significantly higher in the C vs A group (1.38 vs. 0.73, p = 0.00014); and B vs A (1.11 vs. 0.73, p = 0.03). Quicki were lower in C vs. A (0.7 vs. 0.96, p = 0.00068).

Conclusions
The risk of insulin resistance appears to be more associated with lower birth weight than time of birth. No greater risk of insulin resistance has been established in preterm births with AGA.

keywords:

Assessment of insulin resistance in preterm children appropriate for gestational age versus term and preterm children with intrauterine growth restriction

Alicja Korpysz 1 , Marta Wysocka-Mincewicz 1 , Mieczysław Szalecki 1

insulin resistance, AGA preterm, SGA preterm, SGA term

Alicja Korpysz

¹

,

Marta Wysocka-Mincewicz

¹

,

Mieczysław Szalecki

¹