eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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SCImago Journal & Country Rank
3/2019
vol. 36
 
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abstract:
Original paper

Behçet’s syndrome and relationship with the ratio of insulin-like growth factor-1 (IGF-1)/IGF-binding protein-3 (IGFBP-3)

Özlem Doğan
1
,
Emine Ünal
2
,
Üçler Kısa
3
,
Nurkan Aksoy
4

  1. Department of Biochemistry, Medical School, Ankara University, Ankara, Turkey
  2. Department of Dermatology, Yıldırım Beyazıt University, Yenimahalle Training and Research Hospital, Ankara, Turkey
  3. Department of Biochemistry, Medical School, Kırıkkale University, Kırıkkale, Turkey
  4. Department of Biochemistry, Yıldırım Beyazıt University, Yenimahalle Training and Research Hospital, Ankara, Turkey
Adv Dermatol Allergol 2019; XXXVI (3): 295-301
Online publish date: 2019/06/18
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Introduction
Behçet’s syndrome (BS) is a chronic inflammatory disease with unknown aetiology. Insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) have important metabolic properties such as anabolic, cytoprotective and anti-inflammatory effects. Circulating IGF-1 and IGF-1/IGFBP-3 concentrations are associated with adiposity and insulin resistance.

Aim
To determine whether serum IGF-1 and IGFBP-3 levels or IGF-1/IGFBP-3 ratio were associated with the presence or activity of BS.

Material and methods
Forty patients with BS (mean age: 39.6 ±10), and 20 healthy volunteers (mean age: 37 ±10.4) were enrolled. Serum IGF-1, IGFBP-3, and high sensitive C-reactive protein (hs-CRP) and erythrocyte sedimentation rate (ESR) levels were measured in all subjects.

Results
Mean IGF-1 levels were low in both active BS and remission BS compared to the control group and mean IGF-1 levels were similar in active BS and remission BS. In active BS, mean IGFBP-3 levels were higher than in the control group and remission BS. There were positive correlations between these inflammatory cytokines and IGFBP-3 levels. IGF-1/IGFBP-3 ratio was lower in patients with BS compared to the healthy volunteer group, which was statistically significant. IGF-1/IGFBP-3 ratio was lower in BS than in the control group independently of ESR and hs-CRP.

Conclusions
IGF-1 may play a diagnostic role to present itself in BS. IGF-1/IGFBP-3 ratio is not useful as an activation or remission criterion. The ratio may be a useful marker to predict the risk of BS presence in the critical population.

keywords:

Behçet’s syndrome, insulin like growth factor-1, IGF-binding protein-3, inflammation

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