eISSN: 2299-0038
ISSN: 1643-8876
Menopause Review/Przegląd Menopauzalny
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank


2/2019
vol. 18
 
Share:
Share:
abstract:
Original paper

Comparison of clinicopathological features and treatments between pre- and postmenopausal female breast cancer patients – a retrospective study

Servet Kocaöz
1
,
Birol Korukluoğlu
1
,
Ömer Parlak
2
,
Hayriye Tatlı Doğan
3
,
Fazlı Erdoğan
3

  1. Department of General Surgery, Ankara Atatürk Training and Research Hospital, Bilkent, Ankara, Turkey
  2. Department of General Surgery, Faculty of Medicine, Ankara Yıldırım Beyazıt University, Bilkent, Ankara, Turkey
  3. Department of Medical Pathology, Faculty of Medicine, Ankara Yıldırım Beyazıt University, Bilkent, Ankara, Turkey
Menopause Rev 2019; 18(2): 68-73
Online publish date: 2019/06/14
View full text Get citation
 
PlumX metrics:
Introduction
To find out if there are clinical and biological differences in breast cancer characteristics of premenopausal and postmenopausal women. For this reason, we investigated the differences in terms of the clinicopathological features and treatment methods of premenopausal and postmenopausal breast cancer patients in our study.

Material and methods
In this study, the files of 428 patients who were operated due to breast cancer between 1 January 2007 and 31 December 2017 in Ankara Atatürk Training and Research Hospital were examined retrospectively. The age, tumour size, tumour grade, oestrogen receptor, progesterone receptor, HER2 score, Ki-67 proliferation index, perineural invasion, and lymphovascular invasion were investigated.

Results
In patients with premenopausal breast cancer, the tumour diameter was larger (p = 0.047) and the lymph node metastasis was higher (p < 0.001). Oestrogen receptor (OR) expression (p = 0.002), progesterone receptor (PR) expression (p = 0.014), negative human epidermal growth factor receptor 2 (HER2) expression (p = 0.038), and Ki-67 expression (p = 0.017) were higher in the premenopausal group. In the premenopausal group, breast conserving surgery (p = 0.004), chemotherapy (p = 0.007), radiotherapy (p = 0.008), and endocrine therapy (p = 0.025) were higher than in the postmenopausal group.

Conclusions
Premenopausal and postmenopausal female breast cancer patients have significant differences in tumour size, tumour grade, axillary lymph node metastasis, hormone receptor status, HER2 expression, and treatment modalities.

keywords:

breast cancer, hormone receptor, premenopausal, postmenopausal, breast-conserving surgery

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.