Case report
Antiphospholipid syndrome – clinical manifestation, diagnostics and literature review

Antiphospholipid syndrome (APS) is an autoimmune disorder associated with the presence of serum antiphospholipid antibodies (aPL) in patients exhibiting clinical symptoms of venous or arterial thrombosis or recurrent pregnancy morbidity. Antiphospholipid syndrome has a broad spectrum of clinical presentation. According to revised classification criteria, APS is diagnosed if at least one clinical and one laboratory criterion are present (Sydney 2004). In this article a clinical case of a 32-year-old male patient with a 12-month history of extensive symptoms of crural ulcerations resistant to surgical treatment without venous insufficiency and with the presence of lupus anticoagulant in the blood is presented. During hospitalization in the Dermatology Department of the Medical University of Lublin he was diagnosed with primary APS. The patient initially received enoxaparin alone for four days, followed by addition of 6 mg acenocoumarol, then he continued the therapy with acenocoumarol alone. The patient also received sulodexide, pentoxifylline and topical treatment which led to the improvement of his clinical state. Additionally a review of the literature relating to skin involvement in APS syndrome is presented in the article.