Dendritic cells may help differentiate discoid lupus
erythematosus alopecia from lichen planopilaris

Agata Kłosowicz; Maciej Pastuszczak; Grzegorz Dyduch; Adriana Łukasik; Karolina Kozicka; Karolina Englert; Katarzyna Kaleta; Anna Wojas-Pelc

doi:10.5114/ada.2022.115889

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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Original paper

Dendritic cells may help differentiate discoid lupus erythematosus alopecia from lichen planopilaris

Agata D. Kłosowicz

¹

,

Maciej Pastuszczak

¹

,

Grzegorz Dyduch

²

,

Adriana Łukasik

¹

,

Karolina Kozicka

¹

,

Karolina Englert

¹

,

Katarzyna Kaleta

¹

,

Anna Wojas-Pelc

¹

Department of Dermatology, University Hospital, Krakow, Poland
Department of Pathomorphology, Jagiellonian University Medical College, Krakow, Poland

Adv Dermatol Allergol 2022; XXXIX (2): 298-303

DOI: https://doi.org/10.5114/ada.2022.115889

Online publish date: 2022/05/09

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AMA

Kłosowicz AD, Pastuszczak M, Dyduch G, et al. Dendritic cells may help differentiate discoid lupus
erythematosus alopecia from lichen planopilaris. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2022;39(2):298-303. doi:10.5114/ada.2022.115889.

APA

Kłosowicz, A. D., Pastuszczak, M., Dyduch, G., Łukasik, A., Kozicka, K.,  & Englert, K. et al. (2022). Dendritic cells may help differentiate discoid lupus
erythematosus alopecia from lichen planopilaris. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 39(2), 298-303. https://doi.org/10.5114/ada.2022.115889

Chicago

Kłosowicz, Agata D, Maciej Pastuszczak, Grzegorz Dyduch, Adriana Łukasik, Karolina Kozicka, Karolina Englert,  and Katarzyna Kaleta et al. 2022. "Dendritic cells may help differentiate discoid lupus
erythematosus alopecia from lichen planopilaris". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 39 (2): 298-303. doi:10.5114/ada.2022.115889.

Harvard

Kłosowicz, A., Pastuszczak, M., Dyduch, G., Łukasik, A., Kozicka, K., Englert, K., Kaleta, K.,  and Wojas-Pelc, A. (2022). Dendritic cells may help differentiate discoid lupus
erythematosus alopecia from lichen planopilaris. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 39(2), pp.298-303. https://doi.org/10.5114/ada.2022.115889

MLA

Kłosowicz, Agata et al. "Dendritic cells may help differentiate discoid lupus
erythematosus alopecia from lichen planopilaris." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 39, no. 2, 2022, pp. 298-303. doi:10.5114/ada.2022.115889.

Vancouver

Kłosowicz A, Pastuszczak M, Dyduch G, Łukasik A, Kozicka K, Englert K et al. Dendritic cells may help differentiate discoid lupus
erythematosus alopecia from lichen planopilaris. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2022;39(2):298-303. doi:10.5114/ada.2022.115889.

Introduction and aim
Primary cicatricial alopecia (PCA) encompasses a heterogeneous group of inflammatory diseases characterized by the replacement of hair follicle structures by fibrous tissue. Discoid lupus erythematosus (DLE) and lichen planopilaris (LPP) are the most common causes of scarring alopecia. The distinction between both entities is often challenging because of significant clinical and histopathological overlap.
Aim: We hypothesized that dendritic cells which are implicated in PCA pathogenesis can provide a reliable histopathological clue to distinguish between these two entities.

Material and methods
In a retrospective cohort study including 51 patients diagnosed with LPP and DLE we mapped and quantified the distribution of dendritic cells. Cell count in lesional skin was performed on immunohistochemistry by using characteristic monoclonal antibodies to specific subpopulations of dendritic cells.

Results
We demonstrated that almost all subpopulations of dendritic cells were highly expressed in lesional skin of discoid lupus erythematosus patients in comparison with lichen planopilaris ones.

Conclusions
In the light of this observation, dendritic cells might be used as an additional clue in differential diagnosis of PCA.

keywords:

Dendritic cells may help differentiate discoid lupus erythematosus alopecia from lichen planopilaris

Agata D. Kłosowicz 1 , Maciej Pastuszczak 1 , Grzegorz Dyduch 2 , Adriana Łukasik 1 , Karolina Kozicka 1 , Karolina Englert 1 , Katarzyna Kaleta 1 , Anna Wojas-Pelc 1

primary cicatricial alopecia, dendritic cells

Agata D. Kłosowicz

¹

,

Maciej Pastuszczak

¹

,

Grzegorz Dyduch

²

,

Adriana Łukasik

¹

,

Karolina Kozicka

¹

,

Karolina Englert

¹

,

Katarzyna Kaleta

¹

,

Anna Wojas-Pelc

¹