eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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6/2023
vol. 40
 
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abstract:
Original paper

Diagnostic accuracy of peripheral lung function measurements in paediatric asthma control assessment: a pilot study

Maria Wawszczak
1
,
Marek Kulus
1
,
Joanna Peradzyńska
2

  1. Department of Paediatric Pneumonology and Allergy, Medical University of Warsaw, Warsaw, Poland
  2. Department of Epidemiology and Biostatistics, Medical University of Warsaw, Warsaw, Poland
Adv Dermatol Allergol 2023; XL (6): 772-778
Online publish date: 2024/01/08
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Introduction:
Recent studies have indicated the significance of the peripheral airways in asthma control. Methods estimating airway resistance, air trapping, and ventilation inhomogeneity are useful for assessing this area of the lung and have proven utility in the evaluation of asthma; however, it is unclear which method is most effective at characterising uncontrolled asthma.

Aim:
To evaluate the diagnostic accuracy of various peripheral airway function measurements in the assessment of asthma control in children.

Material and methods:
Children with controlled (n = 35) and uncontrolled (n = 29) asthma performed a sequence of pulmonary function tests (i.e. spirometry, body plethysmography, oscillometry, nitrogen washout test, and exhaled nitric oxide). The diagnostic accuracy of each peripheral airway measure was evaluated by an area under the receiver operating characteristic curve (AUC).

Results:
Most peripheral airway parameters were significantly increased in children with uncontrolled asthma compared with children with controlled asthma. The measures with the highest diagnostic accuracy for asthma control were lung clearance index (LCI) (AUC = 0.76), with high specificity (0.97) and modest sensitivity (0.46), acinar ventilation heterogeneity (Sacin) (AUC = 0.73), with high sensitivity (0.85) and modest specificity (0.54), and resonance frequency (Fres) (AUC= 0.74), with perfect specificity (1.0) but low sensitivity (0.38).

Conclusions:
LCI, Sacin and Fres had the highest discriminative capacity for distinguishing children with controlled and uncontrolled asthma among all evaluated peripheral airways measures. Discrepancies in the performance (i.e. sensitivity and specificity) of each parameter suggest that a combination may be most effective in determining asthma control status.

keywords:

impulse oscillometry, nitrogen washout test, body plethysmography, small airways

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