Diagnostic and therapeutic difficulties in the cutaneous form of Langerhans cell histiocytosis in infant

Hubert Arasiewicz; Michał Dec; Lilianna Lesniak-Jakubiec

doi:10.5114/dr.2023.134678

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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5/2023
vol. 110

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Opis przypadku

Diagnostic and therapeutic difficulties in the cutaneous form of Langerhans cell histiocytosis in infant

Hubert Arasiewicz

¹

,

Michał Dec

¹

,

Lilianna Lesniak-Jakubiec

¹

Department of Dermatology and Treatment of Vascular Anomalies for Children, Child and Family Health Center John Paul II, Sosnowiec, Poland

Dermatol Rev/Przegl Dermatol 2023, 615-619

DOI: https://doi.org/10.5114/dr.2023.134678

Data publikacji online: 2024/02/02

Pełna treść artykułu Pobierz cytowanie

Metryki PlumX:

Introduction:
Langerhans cell histiocytosis is an uncommon inflammatory and neoplastic condition of myeloid dendritic cells. Langerhans cell histiocytosis presents with a wide spectrum of clinical manifestations, ranging from single-system involvement to disseminated disease involving multiple organs. Diagnosis is based on a combination of clinical features, radiological findings, and histopathological examination. Positive immunohistochemical staining of lesional cells for CD1a and S100 is necessary for definitive diagnosis of Langerhans cell histiocytosis.

Case report:
Herein, we describe the case of a male infant who presented with multiple erythematous-papular lesions covered with yellow scales on the scalp, temples and face and oozing erythematous and erosive lesions mainly on the abdomen, upper chest, groins, gluteal cleft and armpits.

Conclusions:
Further research is needed to unravel the underlying pathogenesis, develop standardized diagnostic criteria, and improve treatment strategies. Collaboration among various specialties, including dermatology, pediatrics, oncology, radiology, and pathology, is essential for optimal management and long-term follow-up of this complex entity.

POLECAMY

KSIĄŻKI

• Atopowe Zapalenie Skóry • Alergologia – kompendium

Indeks osobowy

Diagnostic and therapeutic difficulties in the cutaneous form of Langerhans cell histiocytosis in infant

Hubert Arasiewicz 1 , Michał Dec 1 , Lilianna Lesniak-Jakubiec 1

Hubert Arasiewicz

¹

,

Michał Dec

¹

,

Lilianna Lesniak-Jakubiec

¹