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ISSN: 2392-1099
Clinical and Experimental Hepatology
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2/2023
vol. 9
 
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abstract:
Original paper

Effects of body composition and liver function after long-term pemafibrate treatment on dyslipidemia-associated non-alcoholic fatty liver disease

Toru Ishikawa
1
,
Nanako Terai
2
,
Takanori Igarashi
1
,
Shun Yamazaki
1
,
Takamasa Kobayashi
1
,
Toshifumi Sato
1
,
Akito Iwanaga
1
,
Tomoe Sano
1
,
Junji Yokoyama
1
,
Terasu Honma
1

  1. Department of Gastroenterology, Saiseikai Niigata Hospital, Niigata, Japan
  2. Department of Radiography, Saiseikai Niigata Hospital, Niigata, Japan
Clin Exp HEPATOL 2023; 9, 2: 172-178
DOI: https://doi.org/10.5114/ceh.2023.127813
Online publish date: 2023/06/23
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Aim of the study:
Owing to the association between non-alcoholic fatty liver disease (NAFLD) and dyslipidemia, there is a need for new treatment strategies to manage both conditions concomitantly. Our aim in this study was to evaluate the effectiveness of pemafibrate in alleviating dyslipidemia-associated NAFLD, including the evaluation of its effects on liver function and body composition.

Material and methods:
The study sample included 67 patients with dyslipidemia-associated NAFLD (29 males, mean age 65.7 years [range, 58.4-73.7]) who were administered pemafibrate continuously for a period of at least 12 months, between June 2019 and January 2022. Outcomes were the change in body composition indices (visceral adipose tissue index – VATI, subcutaneous adipose tissue index – SATI, and skeletal muscle index – SMI), lipid biochemistry, and liver function, reserve, and fibrosis score, from baseline to the 12-month time point of pemafibrate treatment.

Results:
Pemafibrate treatment improved liver function (alanine aminotransferase, aspartate aminotransferase, g-glutamyl transpeptidase, and alkaline phosphatase), and lipid biochemistry (triglycerides and total cholesterol). Improvements in ferritin and hepatic reserve (Mac-2 binding protein, albumin-to-bilirubin score, and NAFLD fibrosis score) were also observed, as well as a decrease in SATI.

Conclusions:
Pemafibrate improved dyslipidemia, liver function, and hepatic reserve. The positive effects of pemafibrate on body composition likely contributed to the improvements in liver function. Longer-term treatment may be necessary to influence VATI and thus to further evaluate the relationship between improved body composition and NAFLD with pemafibrate treatment.

keywords:

non-alcoholic fatty liver disease, pemafibrate, liver function, liver fibrosis, body composition
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