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Journal of Stomatology
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Original paper

Evaluation of efficiency of low-level laser on relapse after orthodontic treatment: a randomized controlled clinical trial

Ousama Abo Ayach
1
,
Rania Hadad
1
,
Omar Hamadah
2

  1. Department of Orthodontics and Dentofacial Orthopedics, Faculty of Dental Medicine, Damascus University, Syria
  2. Department of Oral Medicine, Faculty of Dental Medicine, Damascus University, Syria
J Stoma 2021; 74, 3: 140-146
Online publish date: 2021/08/30
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Introduction

Maintaining the teeth in optimal aesthetic and functional positions after treatment is the most used definition of “retention” that is applied in almost every patient [1]. Despite widespread use of retainers as an essen­tial post-treatment phase, clinicians have not come to a consensus about the necessity of retention, which remains a controversial subject among orthodontists [2, 3]. Although there is a growing trend towards more fixed retention, and so called “invisible retainers” are more used instead of Hawley appliances, the choice of type of orthodontic retainer seems to be mainly based on experience of an orthodontist [4-6]. According to Littlewood et al.’s systematic review, this uncertainty occurs due to large gaps in the literature, providing no evidence of superiority of fixed over removable retainers (or vice versa) in terms of their effectiveness, in addition to limited evidence concerning associated harms, long-term implications, and patient’s compliance [7].
Another dilemma in the orthodontic practice is the required time of retainer’s wear as well as the recommended duration of retention phase [8]. Potential complications associated with prolonged retention, including the periodontium and patient’s compliance, create a uncertainty regarding the need of long-lasting, and indeed, indefinite retention as a long-term experience [9]. The tendency to rapidly reverse orthodontic results has encouraged researches to explore ways to reduce or prevent unwanted movements. A number of pharmacological agents were investigated to reduce the relapse, including local or systemic applications in experimental animals, and some of these factors were found effective [10-15]. Outcomes of these factors varied, but in general, the relapse was alleviated by tissue remodeling around the teeth. Therefore, it is possible to rely on any mechanism that is capable of altering a relapse’s natural process as a support of the retention stage.
Low-level laser therapy (LLLT) has been widely used in dentistry; as non-invasive technique, it is able to produce bio-revitalization effects and thus can be used in the field of stabilizing orthodontic treatment results [16]. In a study, Goulart et al. [17] found that LLL in specific conditions and doses can slow orthodontic movement and therefore, it can be used to prevent a relapse by accelerating the osteogenesis [18, 19]. By reviewing previous research, despite a small amount of clinical studies investigating the effect of LLLT on acceleration of dental movement, there is no study on its effect on recurrence of dental movement after orthodontic treatment. Nevertheless, several studies were exa­mining this issue on animals, and all confirmed the positive effect of LLL on relapse reduction [20-22]. Therefore, the current study aimed to evaluate the effectiveness of 3 protocols of fixed and removable retainers as well as to investigate the effects of low-level laser on the number of relapse and the total duration of retention phase.

Material and methods

This was a 3-arm parallel group, randomized controlled clinical trial, with a 1 : 1 : 1 allocation ratio. The study was ethics committee-approved by the Council of Higher Education and Scientific Research of Damascus University (Ref. No., 5100/2018), and informed consents were obtained from all participants. The study population included 54 patients (29 females and 25 males; between 18 and 26 years of age; mean age, 20.5 ± 1.8 years) who were randomly selected from the Department of Orthodontics and Dentofacial Orthopedics, Faculty of Dental Medicine, Damascus University. All subjects included in this study had to fulfil the following criteria: 1) moderate crowding (4-6 mm) and skeletal angle class I, treated by straightening and alignment without extraction; 2) underwent a successful orthodontic treatment according to the ABO rating system, with less than 20 points; 3) showing with normal growth pattern, normal functional examination, and permanent and complete occlusion; 4) presenting with healthy supportive tissues, good oral hygiene, without absorption in the roots of any of the studied teeth; 5) no previous history of trauma, endodontic treatments, general or local disease, syndromes, or facial and jaw disorders.
Study sample size was determined based on primary objective of comparing the efficacy of each retainer group in preventing the relapse in 1-year post-orthodontic retention. Assuming a change of 0.5 mm as the least clinically significant difference, a common standard deviation of 0.5 mm, a study power of 90%, and a significance level of 5%, each study group required 18 subjects. Having consented to participate in the present study, the subjects were randomly allocated into either upper or lower bonded canine retainers (BRs), vacuum-formed retainers (VFRs), or VFRs with low-level laser (LLL) application. Depending on a computerized randomization program, sequentially numbered, opaque, and sealed envelopes were prepared in advance by an independent person. After the patients’ allocation, and due to the nature of intervention, it was not possible to blind the patients or researchers in this study. Blinding of the outcome assessor investigating the stability was undertaken by replacing the patient’s information on the casts and radio­graphs by a 4-digit code.
Bonded retainers (BRs) were prepared using a 0.0195 in (0.45 mm) 3-stranded twist flex stainless steel wire (Wildcat; GAC International, Bohemia, New York, USA). The wire was shaped by the researcher against the dental casts to passively lie beside lingual surfaces of the upper and lower incisors and canines. The wire was not contoured interproximally. The wire was bonded using a low viscosity light-cured composite (Transbond™ LV; 3M Unitek, Monrovia, California, USA), following separate application of etchant (37% phosphoric acid) and primer (Transbond™ XT adhesive primer; 3M Unitek). Any excess bonding substance in contact with the gingival tissues was carefully removed. VFRs (Essix™ C+) were formed for both groups of removable retainers using Essix™ device. Retainers were made of 1 mm thick, hard, thermoplastic vacuum sheets by standard characteristics for all patients, so that they could cover occlusal surfaces of all erupting teeth and extend over 3-4 mm from gingival margins [23, 24].
The participants in the VFRs only group were instructed to wear their retainers full time for six months, followed by six months of overnight wear, and last six months of intermittent nocturnal use, which is the most commonly used retention protocol [25]. The laser group participants were requested to full time wear their retainers for one month, and then reduce the time of wearing by three hours weekly in second month, so that at the end of that month, only night-time wear was required. This reduction was used only if the patient felt no pressure of the retainer, remained neutral to the teeth, and under weekly supervision of the researcher. At the time of retainer application, both written and verbal oral hygiene instructions were given, including methods for interdental cleaning around BRs.
A continuous 808 nm wavelength with 4 Joules per point power and 15 seconds per point were applied using Klas-DX laser 808 low-level laser device (Konflec Corporation), at the Laser Research Unit, Faculty of Dental Medicine, Damascus University. This is a semi-conductor laser, with gallium aluminum arsenide (Ga-Al-As) as the laser medium. The laser was applied on the root of each of the upper and lower teeth in four points, where the tooth root would theoretically be divided into two halves (cervical and apical) and the head of the device was placed at the buccal side of the root toward the center of each half, in contact with oral mucosa and perpendicularly to the root axis [26]. The laser was re-applied in the same way at the palatal side of the root. The total application time was 60 seconds per tooth. The laser was used on the first day of VFRs application, and then on the 3rd, 7th, and 14th day of the first month. Starting from the second month, it was applied every two weeks, until the patient reached the intermittent wear phase [26].
The primary outcome of the study was to evaluate the clinical effectiveness of the three retainer types in preventing post-treatment changes over the initial 12-months of retention. Post-treatment changes were defined by evaluating the casts using the ABO discrepancy index [27]. Alginate impressions were obtained and measured by the same examiner at three points during the study (T0-T2): T0 at the orthodontic appliances’ debonding, T1 after six months, and T2 after a year of beginning of retention phase. Alignment/ rotation, marginal ridges, buccolingual inclination, overjet, occlusal contacts, occlusal relationship, interproximal contacts, and root angulation were the variables evaluated using cast radiograph evaluation (CRE). Paired t-test was used to compare paired sample means. Analysis of variance tests were applied to compare the means for more than 2 groups. A two-sided 0.05 a level defined a statistical significance.

Results

To identify the overall differences in each element of the American Board of Orthodontics objective grading system (ABO-OGS) during the retention phase irrespective of the type of retainer, paired sample t-test was used to compare the change of variables in all 54 subjects. The differences in alignment/rotation, buccolingual inclination, overjet, interproximal contacts, and total CRE score showed statistical significance from debonding to 1-year recall. However, the differences in marginal ridges, occlusal contacts, occlusal relationship, and root angulation were observed with no statistically significant differences in the same period of observation. While the buccolingual inclination and the occlusal contacts were the only improved variables, the worsening was shown in all the other variables. In total, a worsening of 0.9 point was proved from debonding to 1-year recall as the total CRE increased from 5.6 to 6.5 points in this period of time (Table 1). The comparison of changes in variables in different retention protocols is presented in Table 2. There were statistical differences for alignment/rotation, buccolingual inclination, marginal ridges, occlusal contacts, and interproximal contacts in different retention groups. In contrast, there was no statistical difference between retention protocols for overjet, occlusal relationship, and root angulation. The change of total CRE score from debonding to recall differed significantly among the 3 retention groups (Table 2).
Table 3 shows the comparison between the variables’ means of each retention group at the beginning and the end of the observation period. Only the VFRs LLL group improved in the total CRE score, and this group demonstrated a statistical improvement in 2 variables. The bonded retainer cohort had 2 variables with statistical improvements, but 2 other variables revealed statistical worsening, and the overall CRE change was insignificant. Four variables demonstrated statistically significant worsening in the VFRs group. This cohort demonstrated the least improvement and biggest number of relapses among the 3 retention groups. The average time required to reach 12 hours of retainer’s use in the laser group was 8.33 weeks, which was approximately one-third of the required 24 weeks in the conventional protocol. The required time to reach the intermittent wear use was 25 weeks, which was approximately half of the 52 weeks required in the standard protocol (Table 4).

Discussion

In the literature, different methods were used to eva­­luate the number of relapses. Even though, Little index was used in the study of Forde et al. [28], the majority of studies used a group of casts’ analyzes, with inter-canines width, inter-molars width, length of dental arch, overjet, and overbite [29-31]. In the present study, the ABO objective indicator was used to compare the number of changes in occlusions in different retention protocols. This indicator is widely applied in studies investigating treatments’ effectiveness, and it is based on eight quantitative variables evaluation. Moreover, it is more comprehensive and, unlike other methods, it can reveal a positive change, which is equivalent to an improvement in the occlusion during retention phase [32]. In the present study, a detailed analysis of the components of CRE scores for the whole sample showed that some variables demonstrated an improvement with lower CRE scores at 1 year after the debonding date, including the buccolingual inclination and occlusal contacts. The greatest improvement of CRE score was about 0.3 point in the buccolingual inclination average. In the contrary, an increase could be observed in the alignment/rotation, overjet, and total CRE scores (statistically significant) as well as in the marginal ridges, occlusal relationship, and root angulation (no statistical significance, which can be interpreted as no real change). These changes were interpreted to be signs of relapses or unfavorable tooth movements. The greatest worsening was noted in the alignment/rotation variable, with approximately 0.62 point of change. These settling changes should be considered in the decision to remove orthodontic appliances, as the overall anterior and posterior positions as well as relations of the teeth would not improve during settling phase. In the present study, the improvement of occlusal contacts coincides with previous research [33-35]. Contrary to their findings and on the base of the current study results, it is not advisable for clinicians to neglect the use of occlusal equilibration of cusp tips on the day of debonding, expecting an improvement in the occlusion over a year of settling, since that improvement was questionable.
According to the findings of this study, a less favorable and stable occlusion 1 year after the debonding date can be expected. The average CRE score for the whole study cohort worsened in average by 0.9 point from 5.6 at debond to 6.5 after 1 year of the retention phase. The maximum score of the ABO-OGS for any orthodontic case to be successful according to the ABO is 27 points. On average, all cases included in this study met the board certification standards on the day of debonding and after 1 year of settling, which can mean that the worsening was not clinically significant, and the three retention protocols were effective in preserving orthodontic treatments’ outcomes. The results from this study coincide with those obtained from a study by Greco et al. [36], which showed a worsening in the overall CRE score after the retention period. On the other hand, these results differed from those of two other studies [32, 37], in which the overall CRE score improved after the retention period. However, the results of these three above-mentioned studies were comparable regarding worsening of alignment, improving of buccolingual inclination, and occlusal contacts during the retention period.
In the present study, by comparing the results of total CRE values between the three retention groups at T0, there were no statistically significant differences, which means that the results of orthodontic treatments were close in the three groups to exclude any effect of the initial malocclusion on the degree of relapse among the investigated groups. The results of the ABO index within the same group between the study times showed that (although the total CRE scores worsened in both the BRs and VFRs groups) they remained around 7 points, meaning that both me­thods were effective in stabilizing the results of orthodontic treatments, and this was consistent with most of the previous studies [31].
The worsening in occlusion that was significant only in the VFRs group, contradicts with results of a study by Hoybjerg et al. [32], which compared the change of ABO index using three retention protocols, including BRs and VFRs. They found that the occlusion improved with a decrease in the value of index after one-year observation. This difference can be attributed to the fact that the average value of total CRE in Hoybjerg’s study was significantly higher, ranging between 27 and 29 points at T0. However, it needs to be considered that their study included patients with and without extractions, which could strongly impact the results. Additionally, the current study demonstrated that the overall CRE in the laser group decreased significantly during the first year of retention, which indicates an improvement of the occlusion during this period. This result cannot be compared with previous studies because there are no clinical researches investigating the effect of low-level laser on the occlusal changes during retention stage.
At the end of the observation period, the lowest rate of relapse was among the patients in the laser group, followed by the BRs and VFRs groups. These results were consistent with many previously published studies [9, 28, 38], demonstrating BRs as more effective in resisting relapses than VFRs. Also, the results of the current study agree with the results of a systematic review of Giudice et al. [31] as well as with the results of all studies in the medical literature comparing different retention methods confirming BRs as more effective in preventing relapses than removable appliances. On the other hand, the results of this study differ from those of O’Rourke’s [25], who observed that relapse rate (although it was lower in BRs group after 6 months of retention) became equal to that of VFRs group after one year. This difference can be attributed to the fact that O’Rourke investigated relapse on the lower jaw only and therefore, did not consider occlusal changes. The results of the current research also differ with yet another study [39], which compared the effectiveness of BRs, Hawley device with partial wear, and VFRs with full-time wear. The effectiveness of these three protocols was equal after one year of observation, and this difference could be attributed to small sample size [39].
The retention protocol was adopted in the laser group by starting with a four-week stage of full-time wearing to ensure adequate retention was obtained and a quick relapse during this period was prevented. The time of use was gradually reduced by three hours per week, if the neutrality condition of the retainer was met, depending on the researcher’s careful examination, and the patient’s sensing of the pressure applied by the appliance. The protocol used enabled the determination of required time to wear the retainer without exposing the patient to the risk of a relapse. The average period required to reach the 12-hour wearing time in the laser group was about two months, which was one third of the six months needed in the conventional retention protocol. Additionally, all patients were able to follow the intermittent use of VFRs after thirty weeks of retention. Therefore, the number of hours required to wear VFRs during the day, in addition to the total duration of the retention phase, was statistically and clinically significantly reduced. Unfortunately, these results could not be compared with those from the literature due to lack of clinical studies investigating the effect of LLL on the duration of the retention stage.

Conclusions

With the limitations of the current study, it could be concluded that: 1. During the 1-year of settling phase in both of fixed and removable retainers, only the buccolingual inclination among CRE variables improved significantly. While the alignment, overjet, interproximal contact, and total CRE worsened significantly, the changes in marginal ridges, occlusal contacts, occlusal relationships, and root angulation were insignificant; 2. At the end of the 1-year observation, the BRs, and VFRs retention methods showed a worsening of CRE scores. However, those changes were clinically insignificant, and both methods were effective in stabilizing the results of orthodontic treatments; 3. Using low-level laser (LLL) with VFRs could significantly decrease the relapse level and enhance the overall CRE at the end of observation period; 4. Applying LLL with VFRs may significantly decrease the required time of retainers’ wearing and the overall retention phase.

CONFLICT OF INTEREST

The authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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