eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications
5/2019
vol. 36
 
Share:
Send email
Share:
abstract:
Original paper

Evaluation of periostin level for predicting severity and chronicity of childhood atopic dermatitis

Deniz Ozceker
1
,
Esra Yucel
1
,
Sevgi Sipahi
2
,
Fatih Dilek
3
,
Emin Ozkaya
3
,
Eray Metin Guler
4
,
Abdurrahim Kocyigit
4
,
Nermin Guler
2
,
Zeynep Tamay
2

  1. Department of Pediatric Allergy and Immunology, Okmeydanı Education and Resarch Hospital, Saglik Bilimleri University, Istanbul, Turkey
  2. Department of Pediatric Allergy and Immunology, Istanbul Medical Faculty, Istanbul, Turkey
  3. Department of Pediatric Allergy and Immunology, Bezmi Alem University, Medical Faculty, Istanbul, Turkey
  4. Department of Biochemistry, Bezmi Alem University, Medical Faculty, Istanbul, Turkey
Adv Dermatol Allergol 2019; XXXVI (5): 616-619
DOI: https://doi.org/10.5114/ada.2018.79728
Online publish date: 2018/11/23
View full text Get citation
 
Introduction
Periostin has some effects on the pathogenesis of atopic dermatitis (AD) via release of pro-inflammatory cytokines and chemokines from activated keratinocytes and it is related to chronicity of skin lesions.

Aim
To evaluate the relationship between plasma periostin levels and severity and chronicity of AD in children.

Material and methods
The study population consisted of 29 children with atopic dermatitis without concomitant allergic disease such as asthma or allergic rhinitis and 31 healthy controls. Data of demographic features, serum eosinophil, total IgE and skin prick test results were collected through the patient’s medical records. The severity of the disease was assessed by the SCORAD index. Serum periostin levels were measured with a human periostin ELISA kit.

Results
The mean ages of the AD patients and the control group participants were 80.7 ±52.8 and 90.3 ±41.6 months, respectively. Mean plasma periostin levels were 63.0 ±19.0 ng/ml in AD patients, and 23.6 ±7.3 in healthy controls, and there was a statistically significant difference between the two groups (p = 0.001). Plasma periostin level did not vary according to total IgE or serum eosinophil count (p > 0.05). Age of onset and duration of symptoms also were not correlated with plasma periostin levels. Although there was a positive relationship between plasma periostin level and the SCORAD index of patients, it was not statistically significant (r = 0.19, p > 0.05).

Conclusions
This study showed that plasma periostin levels were increased in children with atopic dermatitis. Periostin may have a partial role in the pathogenesis of atopic dermatitis, but it is not associated with severity or chronicity in children with atopic dermatitis.

keywords:

atopic dermatitis, periostin, eczema, children
FEATURED PRODUCTS
BOOKS
• Atopowe Zapalenie Skóry • Choroby alergiczne w praktyce lekarza rodzinnego • Alergologia – kompendium
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.