eISSN: 2299-0038
ISSN: 1643-8876
Menopause Review/Przegląd Menopauzalny
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1/2023
vol. 22
 
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abstract:
Review paper

Granulosa cell tumour of the ovary complicated by spontaneous haemoperitoneum in menopause – a case report and systematic review of the literature

Gian Luca Babbo
1
,
Guglielmo Stabile
2
,
Maria Sole Scalia
3
,
Serena Nardin
1

  1. Department of Obstetrics and Gynaecology, “San Tommaso dei Battuti” Hospital, Portogruaro, Italy
  2. Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy
  3. Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy
Menopause Rev 2023; 22(1): 49-54
Online publish date: 2023/04/03
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Introduction
A possible cause for acute abdomen is haemoperitoneum resulting from the rupture of an ovarian tumour. Here we discuss a case of spontaneous haemoperitoneum caused by granulosa cell tumour (GCT) rupture in a postmenopausal woman.

Material and methods
We present a systematic review of the current literature to draw attention to this rare gynaecological complication and provide guidance about the most appropriate management.

Results
Eight case reports and one retrospective study were identified. A total of 11 patients were analysed in this review including the present case report. The first case was described in 1948, while the last one was in 2019. The mean age of the patients was 60.8 years. All cases were treated with primary surgery. The mean diameter of the masses was 10.1 cm.

Discussion
We found endometrial pathology in 45% of the cases, of which 4 (36%) were associated with postmenopausal bleeding. The presentation of GCT is not always in the form of overt endocrine disturbance but can onset (10–15%) with acute abdomen.

Conclusions
Granulosa cell tumour should remain in the differential diagnosis of all patients presenting with acute abdomen and imaging suspicious for gynaecological malignancy originating from the ovary.

keywords:

haemoperitoneum granulosa menopause, spontaneous haemoperitoneum, granulosa cell tumour menopause, granulosa cell tumour ovary, pelvic mass

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