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ISSN: 1233-9687
Polish Journal of Pathology
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4/2016
vol. 67
 
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abstract:
Original paper

IgG4-related disease in the head and neck region: report of two cases and review of the literature

Michał Gontarz
,
Grażyna Wyszyńska-Pawelec
,
Jan Zapała
,
Krystyna Gałązka
,
Romana Tomaszewska
,
Agata Lazar

Pol J Pathol 2016; 67 (4): 370-375
DOI: https://doi.org/10.5114/pjp.2016.65871
Online publish date: 2017/02/10
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IgG4-related disease (IgG4-RD) is a rare immune-mediated condition characterized by extensive tissue fibrosis and infiltration by immunoglobulin G4 positive plasma cells in a single organ or systemic appearance. Two cases are presented including an unusual case of a 30-year-old man with IgG4-RD appearing simultaneously in the cervical lymph nodes, ethmoid, maxillary sinuses, and upper gingiva, with spontaneous loss of teeth. According to the literature, this is the first case with loss of teeth occurring in the course of the disease. The second case is a 46-year-old man suffering from IgG4-related chronic sclerosing sialadenitis of the right submandibular gland.
keywords:

IgG4-related disease, head and neck, Küttner tumor, upper respiratory tract
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