Immunological evaluations of women with recurrent pregnancy loss

Tomasz Opala; Jakub Woźniak; Paweł Rzymski; Karolina Chmaj-Wierzchowska; Urszula Winconek-Oberc; Maciej Wilczak

ISSN: 1231-6407

Ginekologia Praktyczna - - - ARCHIVAL

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5/2003
vol. 11

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abstract:

Immunological evaluations of women with recurrent pregnancy loss

Tomasz Opala

,

Jakub Woźniak

,

Paweł Rzymski

,

Karolina Chmaj-Wierzchowska

,

Urszula Winconek-Oberc

,

Maciej Wilczak

Gin Prakt 2003, 11, 5, 2-4

Online publish date: 2003/11/12

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Recurrent miscarriage abortion (RMA), recurrent pregnancy loss (RPL), recurrent spontaneous abortion (RSA), defined as three or more consecutive pregnancy losses before 22 weeks of gestation, affects 0.5–2% of the pregnant.

Half of cases of RMA can be explained by genetic, hormonal, and anatomical factors. Immunologic factors are believed to be the basis of these idiopathic recurrent miscarriages. Normal pregnancy is associated with dominance of T-helper 2 type responses, whereas pregnancy failure is associated with T-helper 1 type responses. Some studies have shown increased production of pro-inflammatory cytokines (TNF-alfa and interferon-gamma) and reduced production of anti-inflammatory cytokines(IL-10). Most RMA are thought to concern normal embryos and loss could be prevented by an immunological treatment in 75–95% of cases, especially if the woman is below 40 years of age.

keywords:

Immunological evaluations of women with recurrent pregnancy loss

Tomasz Opala , Jakub Woźniak , Paweł Rzymski , Karolina Chmaj-Wierzchowska , Urszula Winconek-Oberc , Maciej Wilczak

Recurrent pregnancy loss (RPL), ICAM-1

Tomasz Opala

,

Jakub Woźniak

,

Paweł Rzymski

,

Karolina Chmaj-Wierzchowska

,

Urszula Winconek-Oberc

,

Maciej Wilczak