Immunological relationship between
Helicobacter pylori and anti-tumor necrosis
factor α agents in inflammatory bowel disease

Han Huang; Chenxiao Gan; Yan Cai; Lingkang Wu

doi:10.5114/ceji.2024.136376

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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abstract:

Review paper

Immunological relationship between Helicobacter pylori and anti-tumor necrosis factor α agents in inflammatory bowel disease

Han Huang

¹

,

Chenxiao Gan

¹

,

Yan Cai

^{2, 3, 4}

,

Lingkang Wu

⁵

The Second School of Clinical Medicine, Zhejiang Chinese Medical University, China

School of Basic Medical Sciences, Zhejiang Chinese Medical University,

Key Laboratory of Blood-stasis-toxin Syndrome of Zhejiang Province, China

Traditional Chinese Medicine “Preventing Disease” Wisdom Health Project Research Center of Zhejiang, China

The Second Affiliated Hospital of Zhejiang Chinese Medical University, China

Cent Eur J Immunol 2024; 49 (1)

DOI: https://doi.org/10.5114/ceji.2024.136376

Online publish date: 2024/03/25

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Inflammatory bowel disease (IBD) is a group of diseases characterized by refractory and chronic

inflammation of the bowel, which can be treated with biologics in clinical practice. Anti-tumor necrosis

factor α (TNF-α) agents, which are among the most widely used biologics, alleviate the inflammatory

activity in a variety of ways. Helicobacter pylori is a Gram-negative bacterium that colonizes the gastric mucosa, which could cause chronic inflammation and even induce gastric cancer. However, it has

been suggested that H. pylori has a potential protective role in IBD patients. Yet there has been limited

research on the mechanisms of the effect of H. pylori infection in IBD patients, and whether there is

an interaction between H. pylori and anti-TNF-α agents. This review aims to summarize the possible

mechanisms of H. pylori and anti-TNF-α agents in the development and treatment of IBD, and to

explore the possible interaction between H. pylori infection and anti-TNF-α agents.

keywords:

Immunological relationship between Helicobacter pylori and anti-tumor necrosis factor α agents in inflammatory bowel disease

Han Huang 1 , Chenxiao Gan 1 , Yan Cai 2, 3, 4 , Lingkang Wu 5

cytokines, inflammatory bowel disease, T lymphocytes, Helicobacter pylori, anti-tumor necrosis factor α agents

Han Huang

¹

,

Chenxiao Gan

¹

,

Yan Cai

^{2, 3, 4}

,

Lingkang Wu

⁵