Immunometabolic disorders in the pathogenesis of systemic lupus erythematosus

Kamila Tokarska; Ireneusz Majsterek; Magda Cuchra; Anna Woźniacka

doi:10.5114/ada.2019.85251

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Review paper

Immunometabolic disorders in the pathogenesis of systemic lupus erythematosus

Kamila Tokarska

¹

,

Ireneusz Majsterek

²

,

Magda Cuchra

²

,

Anna Woźniacka

¹

Department of Dermatology and Venereology, Medical University of Lodz, Lodz, Poland
Department of Chemistry and Clinical Biochemistry, Medical University of Lodz, Lodz, Poland

Adv Dermatol Allergol 2019; XXXVI (5): 513-518

DOI: https://doi.org/10.5114/ada.2019.85251

Online publish date: 2019/11/12

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Systemic lupus erythematosus is a chronic autoimmune disease connected with complex and unclear disorders of the immune system, which causes inflammation of body tissues and internal organs. It leads to the formation of anti-nuclear antibodies (ANA) and immune complexes. Numerous immune system disorders and dysfunctions in the biochemical processes can occur in the course of the disease, and a wide range of abnormalities associated with cellular respiratory processes and mitochondrial function have been documented. The following paper presents the current understanding of the contribution of these disorders to the pathogenesis of lupus.

keywords:

Immunometabolic disorders in the pathogenesis of systemic lupus erythematosus

Kamila Tokarska 1 , Ireneusz Majsterek 2 , Magda Cuchra 2 , Anna Woźniacka 1

lupus, mitochondrial dysfunction, necrosis, mtDNA

Kamila Tokarska

¹

,

Ireneusz Majsterek

²

,

Magda Cuchra

²

,

Anna Woźniacka

¹