Interleukin-10 receptor deficiency in a Polish paediatric patient with early onset inflammatory bowel disease

Jarosław Kierkuś; Michał Szczepański; Dorota Gliwicz; Maciej Dądalski; Daniel Kotlarz; Christofer Klein; Józef Ryżko; Piotr Socha

doi:10.5114/pg.2013.36336

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

3/2013
vol. 8

Send email

Copy url:

abstract:

Case report

Interleukin-10 receptor deficiency in a Polish paediatric patient with early onset inflammatory bowel disease

Jarosław Kierkuś

,

Michał Szczepański

,

Dorota Gliwicz

,

Maciej Dądalski

,

Daniel Kotlarz

,

Christofer Klein

,

Józef Ryżko

,

Piotr Socha

Prz Gastroenterol 2013; 8 (3): 202–205

DOI: https://doi.org/10.5114/pg.2013.36336

Online publish date: 2013/07/04

View full text Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Kierkuś J, Szczepański M, Gliwicz D, et al. Interleukin-10 receptor deficiency in a Polish paediatric patient with early onset inflammatory bowel disease. Gastroenterology Review/Przegląd Gastroenterologiczny. 2013;8(3):202-205. doi:10.5114/pg.2013.36336.

APA

Kierkuś, J., Szczepański, M., Gliwicz, D., Dądalski, M., Kotlarz, D.,  & Klein, C. et al. (2013). Interleukin-10 receptor deficiency in a Polish paediatric patient with early onset inflammatory bowel disease. Gastroenterology Review/Przegląd Gastroenterologiczny, 8(3), 202-205. https://doi.org/10.5114/pg.2013.36336

Chicago

Kierkuś, Jarosław, Michał Szczepański, Dorota Gliwicz, Maciej Dądalski, Daniel Kotlarz, Christofer Klein,  and Józef Ryżko et al. 2013. "Interleukin-10 receptor deficiency in a Polish paediatric patient with early onset inflammatory bowel disease". Gastroenterology Review/Przegląd Gastroenterologiczny 8 (3): 202-205. doi:10.5114/pg.2013.36336.

Harvard

Kierkuś, J., Szczepański, M., Gliwicz, D., Dądalski, M., Kotlarz, D., Klein, C., Ryżko, J.,  and Socha, P. (2013). Interleukin-10 receptor deficiency in a Polish paediatric patient with early onset inflammatory bowel disease. Gastroenterology Review/Przegląd Gastroenterologiczny, 8(3), pp.202-205. https://doi.org/10.5114/pg.2013.36336

MLA

Kierkuś, Jarosław et al. "Interleukin-10 receptor deficiency in a Polish paediatric patient with early onset inflammatory bowel disease." Gastroenterology Review/Przegląd Gastroenterologiczny, vol. 8, no. 3, 2013, pp. 202-205. doi:10.5114/pg.2013.36336.

Vancouver

Kierkuś J, Szczepański M, Gliwicz D, Dądalski M, Kotlarz D, Klein C et al. Interleukin-10 receptor deficiency in a Polish paediatric patient with early onset inflammatory bowel disease. Gastroenterology Review/Przegląd Gastroenterologiczny. 2013;8(3):202-205. doi:10.5114/pg.2013.36336.

PlumX metrics:

Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is a chronic condition characterized by abdominal pain, diarrhoea, bleeding, and malabsorption. The disease is common in young people (children and young adults) yet it is rather rare in children younger than 2 years. A distinct phenotype of early onset IBD (EO-IBD) in infants and small children with severe intractable enterocolitis and greater tendency to develop colonic disease has been described. Recent work has demonstrated that EO-IBD with manifestation in the first months of life can be monogenic, resulting from mutations in interleukin-10 (IL-10) or its receptor and leading to a loss of IL-10 function. Allogeneic haematopoietic stem cell transplantation (HSCT) can be a successful treatment for those patients. We present here a case of a female IL-10R-deficient patient with severe EO-IBD who underwent HSCT.

keywords:

Interleukin-10 receptor deficiency in a Polish paediatric patient with early onset inflammatory bowel disease

Jarosław Kierkuś , Michał Szczepański , Dorota Gliwicz , Maciej Dądalski , Daniel Kotlarz , Christofer Klein , Józef Ryżko , Piotr Socha

inflammatory bowel diseases, children, interleukin-10

Jarosław Kierkuś

,

Michał Szczepański

,

Dorota Gliwicz

,

Maciej Dądalski

,

Daniel Kotlarz

,

Christofer Klein

,

Józef Ryżko

,

Piotr Socha