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Diagnostic importance of faecal markers in long-term monitoring of anti-TNF- therapy in primary responders with Crohn’s disease
Liliana Łykowska-Szuber, Katarzyna Klimczak, Piotr Eder, Iwona Krela-Kaźmierczak, Kamila Stawczyk-Eder, Michał Michalak, Adam Studniarek, Tomasz Kościński, Aleksandra Szymczak, Krzysztof Linke
Gastroenterology Rev 2016; 11 (4): 232–238
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Introduction: Monitoring the response to biological treatment in Crohn’s disease (CD) is a very important element of the therapeutic optimisation.
Aim: To evaluate the usefulness of measuring calprotectin, lactoferrin, and myeloperoxidase in stool as markers of long-term clinical and endoscopic response to anti-tumour necrosis factor α (anti-TNF) treatment in CD.
Material and methods: The studied group consisted of 35 CD patients treated with anti-TNF-α antibodies. Clinical activity was evaluated using Crohn’s Disease Activity Index (CDAI), and the exacerbation of endoscopic changes was evaluated using a Simple Endoscopic Score for Crohn’s Disease (SES-CD). The concentration of calprotectin, lactoferrin, and myeloperoxidase was measured using the ELISA method. All measurements were performed three times – before, after 3 months, and after a year of therapy.
Results: During anti-TNF treatment the concentrations of all measured faecal markers decreased significantly in relation to baseline values. We observed a significant correlation at all time-points: before the therapy, after 3 months, and 12 months after starting the therapy, between the concentration of calprotectin and SES-CD, calprotectin and CDAI, as well as between lactoferrin and SES-CD, and lactoferrin and CDAI. Myeloperoxidase correlated with both SES-CD and CDAI only after 1 year of treatment.
Conclusions: Faecal calprotectin and lactoferrin are valuable markers of clinical and endoscopic activity of CD in patients treated with anti-TNF antibodies. They are useful in monitoring the response to treatment. The usefulness of myeloperoxidase in this respect remains controversial.
anti-TNF antibodies, faecal markers, Crohn’s disease
pod redakcją Jarosława Wejmana i Witolda Bartnika
Format: 205 × 290 mm
Liczba stron 180
pod redakcją Andrzeja W. Szawłowskiego i Grzegorza Wallnera
TOM I - Format: B5, liczba stron: 340, oprawa miękka
cena: 92.00 zł
TOM II - Format: B5, liczba stron: 444, oprawa miękka
cena: 92.00 zł
Jean-François Etter, Gérard Mathern
Format: 125x197 mm
Liczba stron: 208
pod redakcją Tomasza Banasiewicza i Macieja Zielińskiego
Liczba stron: 242