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The prevalence of celiac disease in patients with irritable bowel syndrome and its subtypes
Danuta Domżał-Magrowska, Marek K. Kowalski, Piotr Szcześniak, Magdalena Bulska, Daria Orszulak-Michalak, Ewa Małecka-Panas
Gastroenterology Rev 2016; 11 (4): 276–281
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Introduction: Irritable bowel syndrome (IBS) and celiac disease (CD) share some gastrointestinal symptoms. Celiac disease should be considered in a differential diagnosis of IBS.
Aim: To estimate the prevalence of predispositions to CD in patients with IBS and its subtypes.
Material and methods: The study included 48 patients (40 women, 8 men; average age: 41.1 ±14.6 years) with IBS, and a control group: 20 healthy volunteers. All participants completed a questionnaire on their current gastrointestinal symptoms and had a blood sample taken to determine the HLA DQ2/DQ8 antigens and serum concentration of anti-tTG IgA and anti-DGP IgA and IgG.
Results: The presence of HLA DQ2 or DQ8 was found in 50% of patients (n = 24) with IBS. In the control group the presence of HLA DQ2 was found in 4 (20%) patients and nobody had HLA DQ8. Increased levels of anti-tTG IgA were found in 5 (10.42%) patients with IBS, anti-DGP in 4 (8.33%), and anti-DGP IgG in 3 (6.25%). In the control group positive test result for anti-tTG was found in 2 (10%) patients; nobody had elevated anti-DGP IgA or IgG. A concomitant positive result of genetic testing and any elevated serum antibodies specific to CD was found in 12.5% of IBS patients (n = 6) and in none of the control group.
Conclusions: Patients with IBS, regardless of the subtype, significantly more often than healthy controls have the predisposing genetic factors (HLA DQ2/DQ8) underlying the development of CD.
irritable bowel syndrome, celiac disease, HLA-DQ2/DQ8, anti-tTG, anti-DGP
pod redakcją Jarosława Wejmana i Witolda Bartnika
Format: 205 × 290 mm
Liczba stron 180
pod redakcją Tomasza Banasiewicza i Macieja Zielińskiego
Liczba stron: 242
Ragavendra R. Baliga
redaktor wydania polskiego prof. nadzw. dr hab. Maciej Banach
Format: kieszonkowy 110 x 190
Liczba stron 92
Jean-François Etter, Gérard Mathern
Format: 125x197 mm
Liczba stron: 208