eISSN: 2299-0038
ISSN: 1643-8876
Menopause Review/Przegląd Menopauzalny
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4/2023
vol. 22
 
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abstract:
Original paper

Menstrual changes after the thrombo-prophylaxis or anticoagulants used during the COVID-19 infection

Omnia B. Bakr
1
,
Alaa H. El-Feky
1
,
Ibrahim A. Abdelazim
1
,
Rania G. El-Skaan
1

  1. Department of Obstetrics and Gynaecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Menopause Rev 2023; 22(4): 179-185
Online publish date: 2023/12/11
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Introduction
To detect the menstrual changes after the thrombo-prophylaxis or anticoagulants used during the COVID-19 infection.

Material and methods
A total of 176 diagnosed with COVID-19 infection, were included in this retrospective study after giving informed consent. Participants were asked to complete an online questionnaire, and the collected participants` data were analysed using the 2 test to detect the menstrual changes after the thrombo-prophylaxis or anticoagulants used during the COVID-19 infection.

Results
The number of participants` number who reported menstrual flow for 2 to < 5 days, and menstrual flow > 7 days after the COVID-19 infection [31/176 (17.6%), and 42/176 (23.9%), respectively] was significantly higher compared to the number of participants` who reported menstrual flow for 2 to < 5 days, and menstrual flow > 7 days before the COVID-19 infection [12/176 (6.8%), and 15/176 (8.5%), respectively], (p = 0.005, and 0.0009, respectively). The use of thrombo-prophylaxis or anticoagulants during the COVID-19 infection was also associated with significant menstrual pattern changes (37.8% increased menstrual flow, 18.5% menstrual flow for 2 to < 5 days, 59.7% menstrual flow > 7 days, 5.9% contact bleeding, and 6.7% abnormal menstrual pattern for one cycle).

Conclusions
Significant menstrual changes were observed in this study after the COVID-19 infection infection (17.6% reported menstrual flow for 2 to < 5 days, and 23.9% reported menstrual flow > 7 days). The use of thrombo-prophylaxis or anticoagulants during the COVID-19 infection infection was associated with significant menstrual changes (37.8% increased menstrual flow, 18.5% menstrual flow for 2 to < 5 days, 59.7% menstrual flow > 7 days, 5.9% contact bleeding, and 6.7% abnormal menstrual pattern for one cycle).

keywords:

menstrual changes, thrombo-prophylaxis, anticoagulants, COVID-19 infection

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