eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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1/2023
vol. 40
 
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abstract:
Original paper

Molecular peanut sensitization patterns in Lithuanian children with suspected allergic symptoms

Ieva Adomaite
1
,
Evelina Gorbikova
2
,
Monika Miskinyte
3
,
Audrone Eidukaite
2
,
Asta Miskiniene
3
,
Odilija Rudzeviciene
1

  1. Clinic of Children’s Diseases, Faculty of Medicine, Vilnius University, Vilnius, Lithuania
  2. Centre for Innovative Medicine, Vilnius, Lithuania
  3. JSC “In Novum“, Vilnius, Lithuania
Adv Dermatol Allergol 2023; XL (1): 107-110
Online publish date: 2023/02/27
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Introduction:
There are no in-depth studies describing the peanut sensitization molecular patterns in Lithuanian children.

Aim:
To investigate the age-related patterns of molecular peanut sensitization profiles in Lithuanian children with suspected allergic symptoms.

Material and methods:
We performed a retrospective analysis of peanut sensitization profiles in 576 Lithuanian children with possible allergic symptoms. Patient data were categorized according to age groups: 0–2, 3–6, 7–12, and 13–18 years. Specific immunoglobulin E levels to peanut molecular components: Ara h 1, Ara h 2, Ara h 3, Ara h 6, Ara h 8, Ara h 9, Ara h 15, and birch major allergen component Bet v 1 were analyzed.

Results:
Sensitization to at least one peanut protein was observed in 148 (25.7%) children. In children aged ≤ 2 years, most children were sensitized to Ara h 1 – 11 (12.1%). In children aged from 3 to 6 years, the sensitization to Ara h 1 remained the most prevalent in 40 (16.6%) children. The most prevalent sensitization in children aged from 7 to 12 years was to Ara h 8 in 39 (24.5%) of them. In children aged ≥ 13 years, Ara h 8 remained the most prevalent sensitizer in 21 (24.7%) of them.

Conclusions:
One-fourth of children with suspected allergic symptoms are sensitized to at least one peanut molecular component in Lithuania. Infants and preschool children are most commonly sensitized to seed storage proteins, while school-age children to Ara h 8 allergen.

keywords:

component-resolved diagnostics, peanut allergy, food allergy, specific immunoglobulin E

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