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eISSN: 2084-9893
ISSN: 0033-2526
Dermatology Review/Przegląd Dermatologiczny
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SCImago Journal & Country Rank
1/2020
vol. 107
 
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abstract:
Review paper

Psoriatic arthritis – classification, diagnostic and clinical aspects

Paweł Chabros
1
,
Aldona Pietrzak
2
,
Jacek Gągała
1
,
Grzegorz Kandzierski
3
,
Dorota Krasowska
2

  1. Clinic of Orthopaedics and Traumatology, Orthopaedics Department, Medical University of Lublin, Lublin, Poland/Klinika Ortopedii i Traumatologii, Katedra Ortopedii, Uniwersytet Medyczny w Lublinie, Lublin, Polska
  2. Department of Dermatology, Venereology, and Paediatric Dermatology, Medical University of Lublin, Lublin, Poland/Katedra i Klinika Dermatologii, Wenerologii i Dermatologii Dziecięcej, Uniwersytet Medyczny w Lublinie, Lublin, Polska
  3. Orthopaedics and Peadiatric Rehabilitation Department,Univeristy Children's Hospital, Medical University of Lublin, Lublin, Poland/Klinika Ortopedii i Rehabilitacji Dziecięcej, Uniwersytecki Szpital Dziecięcy, Uniwersytet Medyczny w Lublinie, Lublin, Polska
Dermatol Rev/Przegl Dermatol 2020, 107, 32-43
Online publish date: 2020/03/30
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From 5% to 40% patients with psoriatic skin lesions develop psoriatic arthritis, but 15% to 30% of patients with psoriasis suffer from undiagnosed psoriatic arthritis. The key role in development o-f psoriasis is played by T-lymphocytes and release of proinflammatory cytokines, interferon and adhesive proteins. Infection may exert an influence on psoriasis vulgaris and psoriatic arthritis development. The presence of antibodies against the antigens of Yersinia spp., Campylobacter spp. and Chlamydia trachomatis was more frequently observed in the serum of patients with psoriatic arthritis. Diagnosis of psoriatic arthritis may be based on CASPAR criteria. Diagnostic imaging (CT, MRI, USG) are routine diagnostic procedures in psoriatic arthritis. Several sub-types of psoriatic arthritis have been identified. Questionnaires to identify early stages of the disease have been constructed. Genetic factors, cigarette smoking, alcohol abuse, infections, stress and environmental factors may affect clinical course and results of treatment of psoriasis vulgaris and psoriatic arthritis. In severe cases, the disease may lead to disability.
keywords:

psoriasis, psoriatic arthritis, T-lymphocytes, proinflammatory cytokines, diagnosis, therapeutics



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