ISSN: 1641-4640
Folia Neuropathologica
SCImago Journal & Country Rank

Tauopathies: recent insights into old diseases

Andre Delacourte

Folia Neuropathol 2005; 43 (4): 244-257
Neurofibrillary tangles are brain lesions that have been discovered at the beginning of the 20th century, using histological silver staining. Tangles are intra-neuronal hallmarks of a degenerating process: neurofibrillary degeneration (NFD). The basic component involved in tangle formation is tau protein. Tangles are found in more than 20 different neurodegenerative disorders, suggesting that NFD is a unique consequence to different types of etiological factors. However, tangles have a morphological and biochemical signature which is disease-specific. They are made up of different types of filaments such as paired helical filaments (PHFs) in Alzheimer’s disease or straight filaments in progressive supranuclear palsy. Tau aggregates have a disease-specific biochemical bar-code due to the aggregation of specific sets of tau isoforms. Tau lesions have also a disease-specific pattern of spatio-temporal progression in the human brain which is well correlated to cognitive impairment. At last, pathological tau mutations are at the origin of familial fronto-temporal diseases with parkinsonism (FTDP-17). Together, these observations have generated the concept of tauopathies. Indeed, each tauopathy is defined by a combination of clinical, neuropathological, biochemical and genetic features. Most of them have a specific defect on tau (mutation, aberrant splicing, abnormal phosphorylation, abnormal processing, neuronal or genotypic vulnerability), suggesting that, in fact, the etiology of most tauopathies is directly linked to tau dysfunction. In conclusion, we observe that most dementing disorders are tauopathies and that most demented patients have a tauopathy.

Alzheimer’s diesease, tangles, tauopathy, amyloid, neurodegeneration

Featured products
Leczenie padaczki u dzieci i młodzieży
pod redakcją Barbary Steinborn

Format: B5
Liczba stron 224
Oprawa miękka
Umysł w ogniu
Susannah Cahalan
Tłumacz: Aneta Szaraniec
Redakcja merytoryczna: dr psychiatrii FILIP RYBAKOWSKI

Format: 130x197
Liczba stron: 352
Oprawa: miękka ze skrzydełkami
Psychologiczne aspekty stwardnienia rozsianego
pod redakcją Andrzeja Potemkowskiego

format B5
liczba stron 146
oprawa miękka
Leksykon genetyki w psychiatrii
prof. dr hab. n. med. Joanna Hauser, dr n. med. Monika Dmitrzak-Węglarz

Format B5
Liczba stron 168
Oprawa twarda
Studenci Medycyny i Farmacji
Portal adresowanych do studentów uczelni medycznych w Polsce i za granicą.
Copyright notice Privacy policy Advertising policy Contact us
Stosujemy się do standardu HONcode dla wiarygodnej informacji zdrowotnej This site complies with the HONcode standard for trustworthy health information: verify here
Created by Bentus
PayU - płatności internetowe