eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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4/2008
vol. 25
 
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Review paper
Provocation tests for diagnosis of acetylsalicylic acid intolerance

Alicja Kowzan-Korman
,
Magdalena Czarnecka-Operacz
,
Wojciech Silny

Post Dermatol Alergol 2008; XXV, 4: 164–168
Online publish date: 2008/08/25
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Acetylsalicylic acid (ASA) is one of the most commonly used non-steroidal anti-inflammatory drugs. Non-steroidal anti-inflammatory drugs are, after antibiotics, the second most frequent agent causing drug hypersensitivity. ASA intolerance may be accompanied by asthma, nasal polyps and urticaria. Diagnosis of ASA intolerance includes provocation tests: oral, bronchial, intranasal and intravenous (used very rarely, generally only in Japan). Oral and bronchial aspirin challenge are associated with a high risk of severe complications; therefore it is advised to perform them only in specialist diagnostic centres. We would like to accentuate the usefulness of the intranasal provocation test for diagnosis of ASA intolerance as a safe and easy procedure which may be performed in out-patient care.
keywords:

provocation tests, acetylsalicylic acid intolerance
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