eISSN: 2391-517X
ISSN: 2353-9437
Nutrition, Obesity & Metabolic Surgery
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1/2020
vol. 7
 
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abstract:
Original paper

TNF system activity and plasma RBP4 and apelin-36 levels in obese and normal weight women

Wiesław Folwarczny
1
,
Piotr Kocełak
2
,
Aleksander Owczarek
3
,
Jerzy Chudek
2, 4
,
Magdalena Olszanecka-Glinianowicz
1

  1. Health Promotion and Obesity Management Unit, Department of Pathophysiology, Medical Faculty in Katowice, Medical University of Silesia, Katowice, Poland
  2. Pathophysiology Unit, Department of Pathophysiology, Medical Faculty in Katowice, Medical University of Silesia, Katowice, Poland
  3. Department of Statistics, Department of Instrumental Analysis, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland
  4. Department of Internal Medicine and Oncological Chemotherapy, Medical Faculty in Katowice, Medical University of Silesia, Katowice, Poland
Nutrition, Obesity & Metabolic Surgery 2020; 7, 1: 21–26
Online publish date: 2020/05/28
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Objective
Tumour necrosis factor α (TNF-α), retinol-binding protein 4 (RBP4), and apelin-36 are adipokines with increased circulating levels in obesity, which are involved in the development of insulin resistance. It was shown that TNF-α stimulates synthesis of apelin-36 and inhibits RBP4 expression in adipocytes. The aim of the study was the assessment of relationships between TNF system activity and plasma RBP4 and apelin-36 levels in obese and normal weight women.

Material and methods
A total of 116 women (72 obese and 44 normal weight) were enrolled into the study. In addition to the anthropometric measurements and routine biochemical parameters, plasma TNF-α, sTNFRs, RBP4, and apelin-36, insulin levels were assessed by ELISA.

Results
In obese group plasma TNF-α, sTNFR1, RBP-4, and apelin-36 levels were significantly higher, while sTNFR2 levels were lower than in the normal-weight group (Me 4.4 vs. 2.3 pg/mL, p < 0.05; 1908 vs. 1285 pg/mL, p < 0.001; 27.6 vs. 14.7 ng/mL, p < 0.001; 1.6 vs. 1.2 ng/mL, p < 0.05, and 2361 vs. 2574 pg/mL, p < 0.05, respectively). Multivariate regression analysis revealed that plasma RBP4 levels were proportional to age (β = 0.01), and plasma TNF-α (β = 0.26) and sTNFR1 (β = 0.39) levels, and inversely proportional to sTNFR2 levels (β = –0.55) independently of body mass index (BMI) and waist circumference, while apelin-36 was proportional to BMI (β = 0.01) and insulin levels (β = 0.19) and inversely proportional to age (β = –0.01), independently of waist circumference and TNF system activity.

Conclusions
Plasma RBP4, but not apelin-36 level, is associated with TNF system activity.

keywords:

apelin, RBP4, TNF system, nutritional status

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