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Contemporary Oncology/Współczesna Onkologia
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Original paper

The assessment of Dickkopf-1 and Dickkopf-2 protein concentration in different subtypes of non-small cell lung cancer subtypes

Dorota Hudy
1
,
Jadwiga Gaździcka
1
,
Agata Świętek
1
,
Karolina Gołąbek
1
,
Mateusz Rydel
2
,
Damian Czyżewski
2
,
Joanna Katarzyna Strzelczyk
1

1.
Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland
2.
Department of Thoracic Surgery, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland
Contemp Oncol (Pozn) 2024; 28 (1)
Online publish date: 2024/03/27
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1. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021; 71: 209-249.
2. Lu T, Yang X, Huang Y, et al. Trends in the incidence, treatment, and survival of patients with lung cancer in the last four decades. Cancer Manag Res 2019; 11: 943-953.
3. Cancer Stat Facts: Lung and Bronchus Cancer. Available from: https://seer.cancer.gov/statfacts/html/lungb.html (accessed: 20.10.2023).
4. Toumazis I, Bastani M, Han SS, Plevritis SK. Risk-based lung cancer screening: a systematic review. Lung Cancer 2020; 147: 154-186.
5. Corrales L, Rosell R, Cardona AF, Martín C, Zatarain-Barrón ZL, Arrieta O. Lung cancer in never smokers: the role of different risk factors other than tobacco smoking. Crit Rev Oncol Hematol 2020; 148: 102895.
6. Dubin S, Griffin D. Lung cancer in non-smokers. Mo Med 2020; 117: 375-379.
7. Zhang Y, Wang X. Targeting the Wnt/β-catenin signaling pathway in cancer. J Hematol Oncol 2020; 13: 165.
8. Baetta R, Banfi C. DKK (Dickkopf) proteins. Arterioscler Thromb Vasc Biol 2019; 39: 1330-1342.
9. Duchartre Y, Kim YM, Kahn M. The Wnt signaling pathway in cancer. Crit Rev Oncol Hematol 2016; 99: 141-149.
10. Giralt I, Gallo-Oller G, Navarro N, et al. Dickkopf proteins and their role in cancer: a family of Wnt antagonists with a dual role. Pharmaceuticals 2021; 14: 810.
11. Doucet D, Brubaker C, Turner D, Gregory CA. Factors affecting the role of canonical Wnt inhibitor Dickkopf-1 in cancer progression. Front Oncol 2023; 13: 1114822.
12. Lin YF, Li LH, Lin CH, et al. Selective retention of an inactive allele of the DKK2 tumor suppressor gene in hepatocellular carcinoma. PLoS Genet 2016; 12: e1006051.
13. Xu W, Pang K, Zhou ZG, et al. Dickkopf 2 promotes proliferation and invasion via Wnt signaling in prostate cancer. Mol Med Rep 2016; 14: 2283-2288.
14. Gaździcka J, Świętek A, Hudy D, et al. Concentration of secreted frizzled-related proteins (SFRPs) in non-small cell lung carcinoma subtypes – a preliminary study. Curr Oncol 2023; 30: 9968-9980.
15. Brierley JD, Gospodarowicz MK, Wittekind C. TNM classification of malignant tumours. 8th ed. Hoboken NJ: Wiley-Blackwell, Oxford, UK 2017.
16. Świętek A, Gołąbek K, Hudy D, et al. The potential association between E2F2, MDM2 and p16 protein concentration and selected sociodemographic and clinicopathological characteristics of patients with oral squamous cell carcinoma. Curr Issues Mol Biol 2023; 45: 3268-3278.
17. Li S, Qin X, Guo X, et al. Dickkopf-1 is oncogenic and involved in invasive growth in non small cell lung cancer. PLoS One 2013; 8: e84944.
18. Zhang Q, Zhao M, Lin S, et al. Prediction of prognosis and immunotherapy response in lung adenocarcinoma based on CD79A, DKK1 and VEGFC. Heliyon 2023; 9: e18503.
19. Xiang XJ, Liu YW, Chen DD, Yu S. Differential expression of Dickkopf-1 among non-small cell lung cancer cells. Mol Med Rep 2015; 12: 1935-1940.
20. Kim IG, Kim SY, Kim HA, et al. Disturbance of DKK1 level is partly involved in survival of lung cancer cells via regulation of ROMO1 and -radiation sensitivity. Biochem Biophys Res Commun 2014; 443: 49-55.
21. Zhang J, Zhang X, Zhao X, et al. DKK1 promotes migration and invasion of non-small cell lung cancer via β-catenin signaling pathway. Tumor Biol 2017; 39: 101042831770382.
22. Kimura H, Fumoto K, Shojima K, et al. CKAP4 is a Dickkopf1 receptor and is involved in tumor progression. J Clin Invest 2016; 126: 2689-2705.
23. Yao L, Zhang D, Zhao X, et al. Dickkopf-1-promoted vasculogenic mimicry in non-small cell lung cancer is associated with EMT and development of a cancer stem-like cell phenotype. J Cell Mol Med 2016; 20: 1673-1685.
24. Pang H, Ma N, Shen W, et al. Effects of DKK1 overexpression on bone metastasis of SBC-3 cells. Oncol Lett 2018; 15: 6739-6744.
25. Song W, Wu X, Cheng C, Li D, Chen J, Zhang W. ARHGAP9 knockdown promotes lung adenocarcinoma metastasis by activating Wnt/β-catenin signaling pathway via suppressing DKK2. Genomics 2023; 115: 110684.
26. Zhang Y, Yuan J, Guo M, et al. Upregulation of long intergenic non-coding RNA LINC00326 inhibits non-small cell lung carcinoma progression by blocking Wnt/β-catenin pathway through modulating the miR-657/dickkopf WNT signaling pathway inhibitor 2 axis. Biol Direct 2023; 18: 3.
27. Mu J, Hui T, Shao B, et al. Dickkopf-related protein 2 induces G0/G1 arrest and apoptosis through suppressing Wnt/β-catenin signaling and is frequently methylated in breast cancer. Oncotarget 2017; 8: 39443-39459.
28. Hirata H, Hinoda Y, Nakajima K, et al. Wnt antagonist gene DKK2 is epigenetically silenced and inhibits renal cancer progression through apoptotic and cell cycle pathways. Clin Cancer Res 2009; 15: 5678-5687.
29. Hu Z, Wang P, Lin J, et al. MicroRNA-197 promotes metastasis of hepatocellular carcinoma by activating Wnt/β-catenin signaling. Cell Physiol Biochem 2018; 51: 470-486.
30. Zhang X, Li A, Wu J, et al. Promoter methylation analysis of DKK2 may be a potential biomarker for early detection of cervical cancer. Asian Biomed 2022; 16: 181-189.
31. Wang C, Yue Y, Shao B, et al. Dickkopf-related protein 2 is epigenetically inactivated and suppresses colorectal cancer growth and tumor metastasis by antagonizing Wnt/β-catenin signaling. Cell Physiol Biochem 2017; 41: 1709-1724.
32. Deng F, Zhou R, Lin C, et al. Tumor-secreted dickkopf2 accelerates aerobic glycolysis and promotes angiogenesis in colorectal cancer. Theranostics 2019; 9: 1001-1014.
33. Xu W, Pang K, Zhou ZG, et al. Dickkopf 2 promotes proliferation and invasion via Wnt signaling in prostate cancer. Mol Med Rep 2016; 14: 2283-2288.
34. Yang J, Jiang Y, He R, et al. DKK2 impairs tumor immunity infiltration and correlates with poor prognosis in pancreatic ductal adenocarcinoma. J Immunol Res 2019; 2019: 1-12.
35. Hussain M, Rao M, Humphries AE, et al. Tobacco smoke induces polycomb-mediated repression of Dickkopf-1 in lung cancer cells. Cancer Res 2009; 69: 3570-3578.
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