The efficacy of oral glutamine in prevention of acute radiotherapy-induced esophagitis in patients with lung cancer

Oznur Donmez Tutanc; Akin Aydogan; Seckin Akkucuk; Ahmet Taner Sunbul; Seyit Burhanedtin Zincircioglu; Gulistan Alpagat; Ersin Sukru Erden

doi:10.5114/wo.2013.38912

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

6/2013
vol. 17

Send email

Copy url:

abstract:

Original paper

The efficacy of oral glutamine in prevention of acute radiotherapy-induced esophagitis in patients with lung cancer

Oznur Donmez Tutanc

,

Akin Aydogan

,

Seckin Akkucuk

,

Ahmet Taner Sunbul

,

Seyit Burhanedtin Zincircioglu

,

Gulistan Alpagat

,

Ersin Sukru Erden

Contemp Oncol (Pozn) 2013; 17 (6): 520-524

DOI: https://doi.org/10.5114/wo.2013.38912

Online publish date: 2013/12/19

View full text Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Tutanc O, Aydogan A, Akkucuk S, et al. The efficacy of oral glutamine in prevention of acute radiotherapy-induced esophagitis in patients with lung cancer. Contemporary Oncology/Współczesna Onkologia. 2013;17(6):520-524. doi:10.5114/wo.2013.38912.

APA

Tutanc, O., Aydogan, A., Akkucuk, S., Sunbul, A., Burhanedtin Zincircioglu, S.,  & Alpagat, G. et al. (2013). The efficacy of oral glutamine in prevention of acute radiotherapy-induced esophagitis in patients with lung cancer. Contemporary Oncology/Współczesna Onkologia, 17(6), 520-524. https://doi.org/10.5114/wo.2013.38912

Chicago

Tutanc, Oznur Donmez, Akin Aydogan, Seckin Akkucuk, Ahmet Taner Sunbul, Seyit Burhanedtin Zincircioglu, Gulistan Alpagat,  and Ersin Sukru Erden. 2013. "The efficacy of oral glutamine in prevention of acute radiotherapy-induced esophagitis in patients with lung cancer". Contemporary Oncology/Współczesna Onkologia 17 (6): 520-524. doi:10.5114/wo.2013.38912.

Harvard

Tutanc, O., Aydogan, A., Akkucuk, S., Sunbul, A., Burhanedtin Zincircioglu, S., Alpagat, G.,  and Erden, E. (2013). The efficacy of oral glutamine in prevention of acute radiotherapy-induced esophagitis in patients with lung cancer. Contemporary Oncology/Współczesna Onkologia, 17(6), pp.520-524. https://doi.org/10.5114/wo.2013.38912

MLA

Tutanc, Oznur Donmez et al. "The efficacy of oral glutamine in prevention of acute radiotherapy-induced esophagitis in patients with lung cancer." Contemporary Oncology/Współczesna Onkologia, vol. 17, no. 6, 2013, pp. 520-524. doi:10.5114/wo.2013.38912.

Vancouver

Tutanc O, Aydogan A, Akkucuk S, Sunbul A, Burhanedtin Zincircioglu S, Alpagat G et al. The efficacy of oral glutamine in prevention of acute radiotherapy-induced esophagitis in patients with lung cancer. Contemporary Oncology/Współczesna Onkologia. 2013;17(6):520-524. doi:10.5114/wo.2013.38912.

PlumX metrics:

Aim of the study: This study explores the efficacy of oral glutamine in the prevention of acute radiotherapy-induced esophagitis in patients with lung cancer who are treated with thoracic radiotherapy.

Material and methods: This study was planned as a retrospective randomized experimental study. Forty-six patients with lung cancer, who were treated and kept under control between January 2008 and January 2010, were included in the study by the Department of Radiation Oncology, Faculty of Medicine, Dicle University. The patients were divided into two groups. The first group (n = 21) was given prophylactic oral powder glutamine (daily 30 g), while the second group (n = 25) was not given oral glutamine.

Results: There were 21 patients in Group 1 (45.7%) and 25 patients in Group 2 (54.3%). No significant statistical difference was observed between the two groups in terms of age, gender, stage, histopathological type, treatment choice, received radiation doses, esophagus length in RT field, or location of the tumor (p > 0.05). A significant statistical difference was observed between the glutamine-supplemented group (first group) and the glutamine-free group (second group) according to the grade of esophagitis (p < 0.0001).

Conclusions: In our retrospective randomized experimental study, we determined that the severity of acute radiotherapy-induced esophagitis might be decreased with oral glutamine in patients with lung cancer who were treated with thoracic radiotherapy.

keywords:

The efficacy of oral glutamine in prevention of acute radiotherapy-induced esophagitis in patients with lung cancer

Oznur Donmez Tutanc , Akin Aydogan , Seckin Akkucuk , Ahmet Taner Sunbul , Seyit Burhanedtin Zincircioglu , Gulistan Alpagat , Ersin Sukru Erden

acute esophagitis, lung cancer, glutamine, thoracic radiotherapy, radioprotective

Oznur Donmez Tutanc

,

Akin Aydogan

,

Seckin Akkucuk

,

Ahmet Taner Sunbul

,

Seyit Burhanedtin Zincircioglu

,

Gulistan Alpagat

,

Ersin Sukru Erden