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ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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5/2020
vol. 37
 
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abstract:
Original paper

The relationship among androgens, insulin resistance and ghrelin polymorphisms in post-adolescent male patients with severe acne vulgaris

Suzan Demir Pektas
1
,
Nese Cinar
2
,
Deniz Demircioglu Duman
3
,
Ahmet Kara
4
,
Janserey Batu
5
,
Sevim Karakas-Celik
6
,
Duygu Yazgan Aksoy
7

  1. Department of Dermatology, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey
  2. Department of Endocrinology and Metabolic Diseases, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey
  3. Department of Dermatology, Acibadem University, Istanbul, Turkey
  4. Department of Family Medicine, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey
  5. Department of Biochemistry, SYNLAB, Ankara, Turkey
  6. Department of Molecular Biology and Genetic, Faculty of Science, Bulent Ecevit University, Zonguldak, Turkey
  7. Department of Internal Medicine, Acibadem University, Istanbul, Turkey
Adv Dermatol Allergol 2020; XXXVII (5): 800-809
DOI: https://doi.org/10.5114/ada.2020.100492
Online publish date: 2020/11/07
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Introduction
Ghrelin has anti-inflammatory and immunomodulatory activities. Data about the role of ghrelin and ghrelin polymorphisms in the development of acne vulgaris in post-adolescent male patients are limited.

Aim
To evaluate the role of serum androgens, insulin resistance, ghrelin and ghrelin polymorphisms in severe acne vulgaris.

Material and methods
Thirty-five post-adolescent male patients with a mean age of 28.0 ±5.4 years and 33 age-and BMI-matched controls were enrolled. Serum androgens, lipids, insulin sensitivity parameters and ghrelin levels were determined. The PCR method was used for GHRL polymorphisms (rs27647, rs696217 and rs34911341 genotypes).

Results
Patients had similar anthropometric measures to controls, except a significantly higher WHR in patients (0.92 ±0.06 vs. 0.86 ±0.08, p < 0.05). Also, FPG, HOMA-IR values, lipid profile and serum androgen levels were similar. Interestingly, patients had significantly lower ghrelin levels than controls (4.5 ±5.8 vs. 101.2 ±86.5 pg/ml, p < 0.001). The frequencies of rs696217 and rs34911341 genotypes were similar whereas the distribution of rs27647 alleles was significantly different between the groups (p < 0.05). GA and GG genotypes of GHRL rs27647 polymorphism indicated an increased risk of developing acne vulgaris (OR = 11.156, 95% CI: 2.864–43.464, OR = 5.312, 95% CI: 1.269–22.244, respectively; p < 0.05). Patients with rs27647-AA polymorphism had significantly lower GAGS scores than other groups (AA genotype 6.7 ±14.1 vs. GA genotype 24.6 ±15.7 and GG genotype 19.4 ±17.9, p < 0.001). None of the polymorphisms had a significant effect on metabolic parameters, insulin sensitivity and serum ghrelin levels.

Conclusions
Decreased ghrelin levels and GA and GG genotypes of GHRL gene rs27647 polymorphism may have a role in the pathogenesis of acne vulgaris.

keywords:

acne vulgaris, insulin resistance, ghrelin, ghrelin polymorphisms, post-adolescent
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