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eISSN: 2084-9893
ISSN: 0033-2526
Dermatology Review/Przegląd Dermatologiczny
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SCImago Journal & Country Rank
6/2020
vol. 107
 
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abstract:
Review paper

The use of photodynamic therapy in combined treatment of actinic keratosis

Katarzyna Małkińska
1
,
Joanna Bartosińska
2
,
Mirosław Kwaśny
3
,
Dorota Krasowska
4

  1. Klinika Dermatologii, Wenerologii i Dermatologii Dziecięcej, Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie, Polska
  2. Zakład Kosmetologii i Medycyny Estetycznej, Uniwersytet Medyczny w Lublinie, Polska
  3. Instytut Optoelektroniki Wojskowej Akademii Technicznej im. Jarosława Dąbrowskiego w Warszawie, Polska
  4. Katedra i Klinika Dermatologii, Wenerologii i Dermatologii Dziecięcej, Uniwersytet Medyczny w Lublinie, Polska
Dermatol Rev/Przegl Dermatol 2020, 107, 534-545
Online publish date: 2021/02/27
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Actinic keratosis, a type of squamous cell carcinoma in situ, is characterised by hyperkeratotic focal lesions formed on the ultraviolet-damaged skin. Usually, there are a few to several so foci of actinic keratosis, and less often a single lesion is present. The treatment depends on the number, size, duration, and location of lesions. This study discusses some options of combined treatment of actinic keratosis and the possible risk of cancer associated with the use of photodynamic therapy in combination with laser therapy, topical medications (imiquimod, 5-fluorouracil, diclofenac, topical retinoids, ingenol mebutate, calcipotriol), and microneedling. Combined treatment is worth considering in cases of numerous hyperkeratotic foci, particularly in difficult-to-treat locations. Effective photoprotection is essential for all persons with actinic keratosis.
keywords:

actinic keratosis, photodynamic therapy, combined treatment



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