eISSN: 2299-0038
ISSN: 1643-8876
Menopause Review/Przegląd Menopauzalny
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1/2019
vol. 18
 
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abstract:
Review paper

Therapeutic regimens for vitamin D deficiency in postmenopausal women: a systematic review

Yasin Tayem
1
,
Raed Alotaibi
2
,
Reham Hozayen
2
,
Adla Hassan
3

  1. Department of Pharmacology and Therapeutics, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain
  2. Salmaniya Medical Complex, Manama, Bahrain
  3. Department of Medicine, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain
Menopause Rev 2019; 18(1): 57-62
Online publish date: 2019/04/09
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Introduction
We reviewed the most effective vitamin D3 regimen for vitamin D deficiency in postmenopausal women.

Material and methods
We searched for studies and clinical trials conducted on healthy postmenopausal women published on PubMed from 2000 to 2018 using the term “Vitamin D deficiency” combined with the following terms: “dose”, “supplement”, “supplementation”, “cholecalciferol” or “cholecalciferol dose”. We identified 1376 articles which matched the search criteria. Based on reviewing the title and abstract, 17 articles were eligible for a full-text review. Of those, 12 manuscripts were ultimately included.

Results
A majority of the studies (75%) reported using daily maintenance doses which were predominantly administered orally (83.3%). Two studies reported favorable results following therapy with a single oral dose of 300,000 IU. After one month, however, 25-hydroxy vitamin D [25(OH)D] was satisfactory; both studies failed to maintain adequate responses after 60 and 90 days. One study found that loading oral doses of 50,000 IU/day for 2 weeks followed by the same doses every 2 weeks for one year were effective. Five studies employed oral doses of 800 IU/day but none of them reported that this dose was adequate. Three studies used doses of 1000 IU/day but only two of them reported positive results. Three trials examined oral doses of 2000 IU/day and another 3 studies tested oral doses of 4000-4800 IU/day. All of them reported acceptable responses that lasted with continued treatment.

Conclusions
Oral maintenance doses of 2000-4800 IU/day satisfactorily corrected vitamin D deficiency and maintained 25(OH)D levels in postmenopausal women with continuous therapy.

keywords:

vitamin D3, postmenopausal women, vitamin D deficiency

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