Alergologia Polska - Polish Journal of Allergology

Acute anaphylaxis triggered by β-lactam antibiotics: lessons for front-line emergency care

Robin Šín 1, 2
,
Patrik Christian Cmorej 3
,
Alena Lochmannová 4

  1. Faculty of Medicine in Pilsen, Pilsen, Czech Republic

  2. University of West Bohemia, Plzen, Czech Republic

  3. Jan Evangelista Purkyně University, Ústí nad Labem, Czech Republic

  4. Police Academy of the Czech Republic, Prague, Czech Republic

Alergologia Polska – Polish Journal of Allergology

DOI: https://doi.org/10.5114/pja.2026.164678
Data publikacji online: 2026/09/17
Article file
PJA-Acute.pdf
Confronting perimenopausal women’s knowledge of coronary heart disease with their health behaviours. Controversial role of hormone replacement therapy in the protection of coronary heart disease
  1. Luintel A, Healy J, Blank M, et al. The global prevalence of reported penicillin allergy: a systematic review and meta-analysis. J Infect 2025; 90: 106429.
  2. Zavaleta-Monestel E, Webster K, Rojas-Chinchilla C, et al. Management and implications of beta-lactam allergies. Cureus 2024; 16: e60281.
  3. Providencia R, Aali G, Zhu F, et al. Penicillin allergy testing and delabeling for patients who are prescribed penicillin: a systematic review for a World Health Organization guideline. Clin Rev Allergy Immunol 2024; 66: 223-40.
  4. Turner PJ, Campbell DE, Motosue MS, Campbell RL. Global trends in anaphylaxis epidemiology and clinical implications. J Allergy Clin Immunol Pract 2020; 8: 1169-76.
  5. Golden DBK, Wang J, Waserman S, et al. Anaphylaxis: a 2023 practice parameter update. Ann Allergy Asthma Immunol 2024; 132: 124-76.
  6. Macy E. Penicillin allergy: optimizing diagnostic protocols, public health implications, and future research needs. Curr Opin Allergy Clin Immunol 2015; 15: 308-13.
  7. Ben Fadhel N, Aroua F, Chadli Z, et al. Betalactam hypersensitivity: the importance of delabelling in primary care. Br J Clin Pharmacol 2021; 87: 4619-24.
  8. Solensky R. The time for penicillin skin testing is here. J Allergy Clin Immunol Pract 2013; 1: 264-5.
  9. Moussa Y, Shuster J, Matte G, et al. De-labeling of β-lactam allergy reduces intraoperative time and optimizes choice in antibiotic prophylaxis. Surgery 2018; 164: 117-23.
  10. Picard M, Bégin P, Bouchard H, et al. Treatment of patients with a history of penicillin allergy in a large tertiary-care academic hospital. J Allergy Clin Immunol Pract 2013; 1: 252-7.
  11. Sousa-Pinto B, Blumenthal KG, Macy E, et al. Penicillin allergy testing is cost-saving: an economic evaluation study. Clin Infect Dis 2021; 72: 924-38.
  12. Magerčiaková M, Lochmannová A, Mainz D, Debska G. Nursing students’ perceptions of health literacy: a cross-country comparative study. Bratisl Med J 2025; 126: 351-7.
  13. Lochmannová A. Health literacy behind bars: a hidden burden of incarceration. Sociologia 2025; 57: 124-53.
  14. Jeimy S, Ben-Shoshan M, Abrams EM, et al. Practical guide for evaluation and management of beta-lactam allergy: position statement from the Canadian Society of Allergy and Clinical Immunology. Allergy Asthma Clin Immunol 2020; 16: 95.
  15. Liang EH, Chen LH, Macy E. Adverse reactions associated with penicillins, carbapenems, monobactams, and clindamycin: a retrospective population-based study. J Allergy Clin Immunol Pract 2020; 8: 1302-13.e2.
  16. Cardona V, Ansotegui IJ, Ebisawa M, et al. World Allergy Organization anaphylaxis guidance 2020. World Allergy Organ J 2020; 13: 100472.
  17. Cardona V, Ferré-Ybarz L, Guilarte M, et al. Safety of adrenaline use in anaphylaxis: a multicentre register. Int Arch Allergy Immunol 2017; 173: 171-7.
  18. Campbell RL, Bellolio MF, Knutson BD, et al. Epinephrine in anaphylaxis: higher risk of cardiovascular complications and overdose after administration of intravenous bolus epinephrine compared with intramuscular epinephrine. J Allergy Clin Immunol Pract 2015; 3: 76-80.
  19. Patel N, Chong KW, Yip AYG, et al. Use of multiple epinephrine doses in anaphylaxis: a systematic review and meta-analysis. J Allergy Clin Immunol 2021; 148: 1307-15.
  20. Resuscitation Council UK. Emergency treatment of anaphylactic reactions: Guidelines for healthcare providers. 2021. Available from: https://www.resus.org.uk/library/additional-guidance/guidance-anaphylaxis/emergency-treatment (accessed June 16, 2025).
  21. Muraro A, Roberts G, Worm M, et al. Anaphylaxis: guidelines from the European Academy of Allergy and Clinical Immunology. Allergy 2014; 69: 1026-45.
  22. O’Driscoll BR, Howard LS, Earis J, Mak V. British Thoracic Society guideline for oxygen use in adults in healthcare and emergency settings. BMJ Open Respir Res 2017; 4: e000170.
  23. Simons FER, Ardusso LRF, Bilò MB, et al. World Allergy Organization guidelines for the assessment and management of anaphylaxis. World Allergy Organ J 2011; 4: 13-37.
  24. Sheikh A, Ten Broek V, Brown SGA, Simons FER. H1-antihistamines for the treatment of anaphylaxis: Cochrane systematic review. Allergy 2007; 62: 830-7.
  25. Dodd A, Hughes A, Sargant N, et al. Evidence update for the treatment of anaphylaxis. Resuscitation 2021; 163: 86-96.
  26. Shaker MS, Wallace DV, Golden DBK, et al. Anaphylaxis – a 2020 practice parameter update, systematic review, and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) analysis. J Allergy Clin Immunol 2020; 145: 1082-123.
  27. Kato T, Mizuno T, Nakanishi M, et al. Efficacy of ascorbic acid, thiamine, and hydrocortisone combination therapy: meta-analysis of randomized controlled trials. In Vivo 2023; 37: 1236-45.
Copyright: © Polish Society of Allergology This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivatives 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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