eISSN: 2299-0038
ISSN: 1643-8876
Menopause Review/Przegląd Menopauzalny
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vol. 19
Special paper

Age of natural menopause onset in BRCA1/2 carriers – systematic review and meta-analysis

Łukasz Kępczyński
Katarzyna Połatyńska
Anna Nykel
Jordan Sałamunia
Tadeusz Kałużewski
Andrzej Kużawczyk
Agnieszka Gach

  1. Department of Genetics, Polish Mother’s Memorial Hospital Research Institute, Lodz, Poland
  2. Department of Neurology, Polish Mother’s Memorial Hospital Research Institute, Lodz, Poland
  3. Laboratory of Medical Genetics of the “Genos” Partnership R&D Division, Lodz, Poland
  4. Institute IURISMED – Independent Medical Examiners, Kutno, Poland
Menopause Rev 2020; 19(4): 171-173
Online publish date: 2021/01/07
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Germinal pathogenic variants in BRCA1 and BRCA2 genes are associated with high risk of cancers, including breast, ovary, fallopian tubes and primary peritoneal. Non-oncological implications of germline pathogenic variants in BRCA1 and BRCA2 genes, complicating reproductive health are less described. The influence of BRCA1 and BRCA2 on age of natural menopause remains inconclusive and controversial.

Material and methods
PubMed database was searched for potentially relevant abstracts. Studies which were not case-control, cohort or cross-sectional studies were subsequently excluded. Reference lists from systematic reviews or meta-analyses, dealing with the topic of menopause and BRCA1 and BRCA2 germinal pathogenic variants, were also checked to identify eligible studies. We also included our original, unpublished data from families, affected by BRCA1 or BRCA2 pathogenic variant, consisted of at least two postmenopausal female siblings with differing variant status.

Results and conclusions
Initial database search retrieved 193 abstracts. We identified 4 eligible studies for meta-analysis. Two studies not reporting dispersion measures and not reporting age of natural menopause in control group were left in summary for illustrational purposes, yet were excluded from meta-analysis. 4 studies and our original, unpublished data, combining data from 1535 germinal BRCA1 and BRCA2 pathogenic variant carriers and 3191 control individuals, did not support the hypothesis of association between germinal pathogenic variants of “breast cancer genes” and premature menopause.


BRCA1, BRCA2, menopause

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