Antibiotic hypersensitivity in children: diagnostic challenges illustrated by a case series
Department of Paediatrics, Allergology and Gastroenterology, Collegium Medicum in Bydgoszcz
Nicolaus Copernicus University in Torun, Poland
Alergologia Polska – Polish Journal of Allergology
Data publikacji online: 2026/09/17
- Berges-Gimeno MP, Alvarez-Cuesta E, Atanaskovic-Markovic M, et al. Drug hypersensitivity reactions in children in clinical practice: a WAO Statement. World Allergy Organization J 2025; 18: 101087.
- Sousa-Pinto B, Almeida-Fonseca J, Rebelo Gomes E. Frequency of self-reported drug allergy: a systematic review and meta-analysis with meta-regression. Ann Allergy Asthma Immunol 2017; 119: 362-73.
- Capanoglu M, Erkocoglu M, Kaya A, et al. Confirmation of drug allergy in a general pediatrics outpatient clinic. Ann Allergy Asthma Immunol 2022; 129: 784-9.
- Piccorossi A, Liccioli G, Barni S, et al. Epidemiology and drug allergy results in children investigated in allergy unit of a tertiary-care paediatric hospital setting. Ital J Pediatr 2020; 46: 5.
- Raport: Monitorowanie zużycia antybiotyków w lecznictwie otwartym za rok 2024. https://antybiotyki.edu.pl/wp-content/uploads/2026/01/Raport-NPZ-4.1-Konsumpcja-otwarte-2024_2025-12-22.pdf
- Taylor MG, Joerger T, Li Y, et al. Factors associated with penicillin allergy labels in electronic health records of children in 2 large US pediatric primary care networks. JAMA Netw Open 2022; 5: e222117.
- Daghfous H, Moussa C, Ben Mansour A, et al. Drug reintroduction testing and beta-lactam hypersensitivity in children: protocols and results, a 12-year experience. Int J Immunopathol Pharmacol 2023; 37: 03946320231204220.
- Rubio M, Bousquet J, Gomes E, et al. Result of drug hypersensitivity evaluations in a large group of children and adults. Clin Exp Allergy 2012; 42: 123-30.
- Caubet JC, Kaiser L, Lemaitre B, et al. The role of penicillin in benign skin rashes in childhood: a prospective study based on drug rechallenge. J Allergy Clin Immunol 2011; 127: 218-22.
- Copaescu A, Li L, Blumenthal K, Trubiano J. How to define and manage low-risk drug allergy labels. J Allergy Clin Immunol Pract 2024; 12: 1095-106.
- Jones TW, Fino N, Olson J, et al. The impact of beta lactam allergy labels on hospitalized children. Infect Control Hosp Epidemiol 2021; 42: 318-24.
- Lucas M, Arnold A, Sommerfield A, et al. Antibiotic allergy labels in children are associated with adverse clinical outcomes. J Allergy Clin Immunol Pract 2019; 7: 975-82.
- Milosevic K, Malinic M, Plavec D, et al. Diagnosing single and multiple drug hypersensitivity in children: a tertiary care center retrospective study. Children 2022; 9: 1954.
- Vyles D, Adams J, Chiu A, et al. Allergy testing in children with low-risk penicillin allergy symptoms. Pediatrics 2017; 140: e20170471.
- Macy E, Poon KYT. Self-reported antibiotic allergy incidence and prevalence: age and sex effects. Am J Med 2009; 122: 778.e1-7.
- Doña I, Caubet JC, Brockow K, et al. An EAACI task force report: recognising the potential of the primary care physician in the diagnosis and management of drug hypersensitivity. Clin Transl Allergy 2018; 8: 16.
- Abrams E, Netchiporouk E, Miedzybrodzki B, et al. Antibiotic allergy in children: more than just a label. Int Arch Allergy Immunol 2019; 180: 103-12.
- Ben Romdhane H, Ben Fredj N, Ben Fadhel N, et al. Beta-lactam hypersensitivity in children: frequency and risk factors. Br J Clin Pharmacol 2023; 89: 150-7.
- Ibáñez MD, Rodríguez Del Río P, Lasa EM, et al. Prospective assessment of diagnostic tests for pediatric penicillin allergy: from clinical history to challenge tests. Ann Allergy Asthma Immunol 2018; 121: 235-44.e233.
- Karavaizoglu C, Suleymana A, Yavuz Alıc R, et al. Drug allergy in children: adverse reactions after skin testing. Int Arch Allergy Immunol 2024; 185: 56-62.
- Blanca-Lopez N, Atanaskovic-Markovic M, Gomes ER, et al. An EAACI task force report on allergy to beta-lactams in children: clinical entities and diagnostic procedures. Pediatr Allergy Immunol 2021; 32: 1426-36.
- Zambonino MA, Corzo JL, Muñoz C, et al. Diagnostic evaluation of hypersensitivity reactions to beta-lactam antibiotics in a large population of children. Pediatr Allergy Immunol 2014; 25: 80-7.
- Ponvert C, Perrin Y, Bados-Albiero A, et al. Allergy to beta-lactam antibiotics in children: results of a 20-year study based on clinical history, skin and challenge tests. Pediatr Allergy Immunol 2011; 22: 411-8.
- Regateiro FS, Rezende I, Pinto N, et al. Short and extended provocation tests have similar negative predictive value in non-immediate hypersensitivity to beta lactams in children. Allergol Immunopathol 2019; 47: 477-83.
- Chiriac AM, Rerkpattanapipat T, Bousquet PJ, et al. Optimal step doses for drug provocation tests to prove beta-lactam hypersensitivity. Allergy 2017; 72: 552-61.
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