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ISSN: 2353-3854
Alergologia Polska - Polish Journal of Allergology
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1/2021
vol. 8
 
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abstract:
Review paper

Asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome and the risk of severe COVID-19

Klaudia Waszczykowska
1
,
Marta Węgierska
1
,
Roxana Drygała
1
,
Rafał Pawliczak
1

1.
Department of Immunopathology, Medical Faculty, Medical University of Lodz, Lodz, Poland
Alergologia Polska – Polish Journal of Allergology 2021; 8, 1: 21–30
Online publish date: 2021/03/23
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Asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome (ACOS) significantly affect the patient’s respiratory system, which requires individualised treatment and professional control. During the SARS-CoV-2 pandemic, all respiratory diseases were taken into consideration as risk factors for severe COVID-19. ACE2 and TMPRSS2 genes, which are crucial for SARS-CoV-2 to enter the host cell, have different expression in the occurrence of asthma or COPD. Also, comparing the severity and mortality of patients with coexistence of asthma or COPD and COVID-19, only COPD patients had worse outcomes of COVID-19, and their mortality was significantly higher. Although ACOS is also a potential risk factor for hospitalisation and mortality in COVID-19 patients, the condition still requires further studies. This overview presents the current state of knowledge on the relationship between the diseases mentioned above and COVID-19.
keywords:

bronchial asthma, chronic obstructive pulmonary disease (COPD), asthma-COPD overlap syndrome, COVID-19, SARS-CoV-2

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