Automated EQD2 reporting for cervical cancer high-dose-rate brachytherapy using a standalone ESAPI-based application
Department of Physics, Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia
Center for Radiotherapy, International Medical Centers, Banja Luka, Bosnia and Herzegovina
Faculty of Electrical Engineering, University of Banja Luka, Banja Luka, Bosnia and Herzegovina
Faculty of Medicine, University of Banja Luka, Banja Luka, Bosnia and Herzegovina
Faculty of Natural Sciences and Mathematics, University of Banja Luka, Banja Luka, Bosnia and Herzegovina
J Contemp Brachytherapy
Data publikacji online: 2026/06/08
-
- International Commission on Radiation Units and Measurements. Dose and volume specification for reporting intracavitary therapy in gynecology. ICRU Report 38. ICRU, Bethesda, MD 1985.
- Viswanathan AN, Creutzberg CL, Craighead P et al. International brachytherapy practice patterns: a survey of the Gynecologic Cancer Intergroup (GCIG). Int J Radiat Oncol Biol Phys 2012; 82: 250-255.
- Visser AG, Symonds RP. Dose and volume specification for reporting gynaecological brachytherapy: time for a change. Radiother Oncol 2001; 58: 1-4.
- Srivastava
A, Datta NR. Brachytherapy in cancer cervix: time to move ahead from
point A? World J Clin Oncol
2014; 5:
764-774. - Pötter R, Haie-Meder C, Van Limbergen E et al. Recommendations from gynaecological (GYN) GEC-ESTRO Working Group (II): concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy – 3D dose-volume parameters and aspects of 3D image-based anatomy, radiation physics, and radiobiology. Radiother Oncol 2006; 78: 67-77.
- International Commission on Radiation Units and Measurements. Prescribing, Recording, and Reporting Brachytherapy for Cancer of the Cervix. ICRU Report 89. J ICRU 2016; 16: 1-138.
- EMBRACE Study. EMBRACE Studies and EMBRACE Research. Aarhus; 2025. Available at: https://www.embracestudy.dk/Public/Default.aspx?ReturnUrl=%2f&AspxAutoDetectCookieSupport=1 (accessed September 23, 2025).
- Pötter R, Tanderup K, Kirisits C et al. The EMBRACE II study: the outcome and prospect of two decades of evolution within the GEC-ESTRO GYN Working Group and the EMBRACE studies. Clin Transl Radiat Oncol 2018; 9: 48-60.
- American Brachytherapy Society. Physics Corner. ABS; Reston. Available at: https://www.americanbrachytherapy.org/learning-resources/physics-corner/ (accessed September 23, 2025).
- Department of Radiotherapy and Radiobiology, Medical University of Vienna. HDR-GYN Biol-Physik-Formular. Vienna; 2017. Available at: https://www.embracestudy.dk/UserUpload/PublicDocuments/Docs/HDR-GYN_Biol-Physik-Formular_2017.xls (accessed September 23, 2025).
- Faught AM, Chino JP, Chang Z et al. Using Varian’s Eclipse Scripting API to calculate, add, and report biologically equivalent doses for gynecological brachytherapy and external beam radiation therapy patients. Brachytherapy 2016; 15: S137-S138.
- Salerno M, Hubley E, Anamalayil S et al. PO0214: development of an Eclipse script for automatic calculation of EQD2 in combined external beam radiation therapy and high-dose-rate gynecologic brachytherapy. Brachytherapy 2024; 23: S100.
- Cheng K, Ragab O, Momin F et al. Automation of dosimetric data collection using C# ESAPI for intracavitary and hybrid intracavitary/interstitial brachytherapy plans. Int J Radiat Oncol Biol Phys 2023; 117: e506-e507.
- Cheng G, Mu X, Liu Y et al. Predictive value of Excel forms based on an automatic calculation of dose equivalent in 2 Gy per fraction in adaptive brachytherapy for cervical cancer. J Contemp Brachytherapy 2020; 12: 454-461.
- Mroué A, Kang H, Hasan Y et al. Automation of treatment planning goals documentation in HDR brachytherapy. Brachytherapy 2016; 15: S167.
- Siavashpour Z, Farajollahi F, Aghamiri SMR et al. A comparison of manual and automatic methods for calculating cumulative dose-volume histogram parameters in cervical cancer radiotherapy. Int J Cancer Manag 2024; 17: e156839.
- Varian Medical Systems. Eclipse Scripting API Reference Guide. Version P1015247-001-A. Varian Medical Systems; Palo Alto 2016. Available at: https://varianapis.github.io/VarianApiBook.pdf (accessed September 23, 2025).
- Dale RG. The application of the linear-quadratic dose-effect equation to fractionated and protracted radiotherapy. Br J Radiol 1985; 58: 515-528.
- Withers HR, Thames HD Jr, Peters LJ. A new isoeffect curve for change in dose per fraction. Radiother Oncol 1983; 1: 187-191.
- Joiner MC, van der Kogel AJ (Eds.). Basic Clinical Radiobiology. CRC Press, Boca Raton 2018.
- Kim H, Lee YC, Benedict SH et al. Dose summation strategies for external beam radiation therapy and brachytherapy in gynecologic malignancy: a review from the NRG Oncology and NCTN Medical Physics Subcommittees. Int J Radiat Oncol Biol Phys 2021; 111: 999-1010.
- Varian Medical Systems. Varian Code Samples: DVH Lookup Tool. GitHub; 2018. Available at: https://github.com/VarianAPIs/Varian-Code-Samples (accessed September 23, 2025).
- Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Routledge, New York 1988.
- Huq MS, Fraass BA, Dunscombe PB et al. Report of TG-100: risk analysis in radiotherapy quality management. Med Phys 2016; 43: 4209-4226.
- Fröhlich G, Vízkeleti J, Nguyen AN et al. Comparative analysis of image-guided adaptive interstitial brachytherapy and intensity-modulated arc therapy versus conventional treatment techniques in cervical cancer using biological dose summation. J Contemp Brachytherapy 2019; 11: 69-75.
Copyright: © 2026 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
