With delight we present you the agenda for the Nucletron Central Europe Users Meeting, which will be held on 15-17 October 2009 in Budapest, Hungary. We have aimed for an inspiring programme that looks at brachytherapy from both a scientific and a practical perspective. A Toolkit for Good Medical Practice in Brachytherapy is therefore the theme for this meeting. A host of nationally and internationally renowned experts will address all significant aspects in a series of interactive talks, discussions and video demonstrations. In addition to sharing experiences and giving feedback on new Nucletron technology, we want to focus on how to successfully implement clinical protocols and procedures that drive good-quality results within the technological and socio-economic context of Central Europe. Brachytherapy has always been the mainstay for treating gynaecological cancers and in fact the standard of care in Central Europe. Going forward, brachytherapy will play an even more crucial role, not only because of the rising incidence of indications like prostate and breast cancer but primarily because of its proven efficacy and efficiency in treating these diseases. At the same time, clinical and technological developments are driving the transition from 2-D (implant-based) to 3-D (volume-based) treatment planning and reinforcing the use of image-guidance for (interstitial) applications. These important developments offer vital inspiration for exploring and discussing sensible solutions that are relevant for your practice. That is why this year’s Central Europe Users Meeting will focus on the opportunity to expand from GYN to other body sites and the benefit from key advancements in image-guided and adaptive brachytherapy by using knowledge and technology that is currently available to you. This meeting intends to offer you a toolkit for expanding the extraordinary potential of brachytherapy by breaking the barriers through clinical proof, cost-effectiveness and education.
Scientific Committee Chairmen • Csaba Polgár MD PhD (Budapest) • Tibor Major PhD (Budapest)
Members • Péter Ágoston MD PhD (Budapest) • Jenő Bolgár MD (Kecskemét, HU) • Janaki Hadijev MD PhD (Kaposvár, HU) • János Fodor MD PhD DSc (Budapest) • Erika Groska MSc (Gyula, HU) • László Mangel MD PhD (Pécs, HU) • József Lövey MD PhD (Budapest) • Jenő Pálvölgyi PhD (Győr, HU) • Béla Pikó MD (Gyula, HU) • Kofi Agyemang Prempeh MD (Győr, HU) • Kornélia Szluha MD PhD (Debrecen, HU) • László Takácsi-Nagy MD PhD (Budapest) • Zoltán Takácsi-Nagy MD PhD (Budapest) • Prof László Thurzó MD PhD (Szeged, HU)
International Invited Speakers • Prof Dimos Baltas PhD DSc (Offenbach, DE) • Catharina Beskow MD PhD (Stockholm, SE) • Brygida Białas MD PhD (Gliwice, PL) • Michel Ghilezan MD (Royal Oak, MI USA) • Bengt Johansson MD (Örebro, SE) • Prof Christian Kirisits PhD DSc (Vienna, AT) • Gábor Kacso MD PhD (Cluj-Napoca, RO) • Anna Kulik MD PhD (Warsaw, PL) • Jarosław Łyczek MD PhD (Warsaw, PL) • Prof Bogusław Maciejewski MD PhD DSc (Gliwice, PL) • Prof Julian Malicki PhD DSc (Poznań, PL) • Maryla Kawczyńska PhD (Warsaw, PL) • Primož Petrič MD (Ljubljana, SLO) • Prof Pavel Slampa MD PhD (Brno, CZ) • Prof Andrzej Roszak MD PhD DSc (Poznań, PL) • Prof Janusz Skowronek MD PhD DSc (Poznań, PL) • Prof Renata Soumarová MD PhD (Novy Jicín, CZ) • Grzegorz Zwierzchowski MD PhD (Poznań, PL)
Nucletron Speakers • Else Meijer MSc • Eric Sewsingh BSc • Lisette van der Vight BSc • Mehmet Üzümcü PhD Organisers National Institute of Oncology – Budapest • Csaba Polgár MD PhD • Tibor Major PhD • Péter Ágoston MD
Nucletron – Netherlands • Antar El-Mecky MA • Jeske van der Sluijs • Hans Galesloot MBA
12.00-14.30 Registration
OPENING CEREMONY
14.30-14.45 Welcome Speeches
Csaba Polgár, Head of Radiotherapy NIO, Budapest and Jos Lamers, CEO Nucletron
14.45-15.00 Speeches by Honorary Patrons
Prof Dr Miklós Kásler, Director NIO, Budapest and László Mangel,
President of the Hungarian Society for Radiation Oncology
ORAL SESSION I: BREAST BRACHYTHERAPY – MULTICATHETER APBI
Chairpersons: Anna Kulik and János Fodor
15.00-15.20 Current Status and Future Perspectives of Multicatheter Breast Brachytherapy
Csaba Polgár
15.20-15.35 LDR and HDR Multicatheter APBI:12-Year Result of William Beaumont Hospitals, Royal Oak, MI, USA
Michel Ghilezan
15.35-15.50 HDR Multicatheter Brachytherapy for APBI: Technique and Long-Term Results of Örebro University Hospital
Bengt Johansson
15.50-16.00 Discussion
Anna Kulik and János Fodor
16.00-16.30 Coffee Break
16.30-16.50 VIDEO PRESENTATION I
Breast Implantation Using Nucletron Comfort™ Catheters and Oncentra® Brachy Treatment Planning System
Tibor Major
16.50-17.10 New Technology for Breast Brachytherapy
Grzegorz Zwierchowski and Else Meijer
17.10-17.30 Discussion
Anna Kulik and János Fodor
ROUND-TABLE DISCUSSION I: BREAST BRACHYTHERAPY
Chairman: Jarosl/aw L/yczek
17.30-18.15 Should We Keep our Good Old Breast Implant Techniques and 2-D Planning or Should We Go for CT-Based
Conformal Brachytherapy Planning?
Michel Ghilezan, Bengt Johansson, Christian Kirisits, Tibor Major, Csaba Polgár,
Pavel Slampa
ORAL SESSION II: PROFERRED PAPERS ON BREAST BRACHYTHERAPY
Chairmen: Bengt Johansson and Pavel Slampa
18.15-18.40 3-D CT-Based HDR Interstitial BT for Localised Breast Cancer
– Plan Evaluation: M.S. Patel
Cancer Centre Experience
Ganesan Senthil
18.40-19.00 IPSA vs. Geometry-Based Optimisation in Dose Distribution Calculation in Accelerated Partial Breast Irradiation
Marta Szlag
20.00 Dinner
Friday 16th October 2009
ORAL SESSION III: IS THERE ARE A ROLE FOR PREOPERATIVE BRACHYTHERAPY IN TREATING GYN TUMOURS?
Chairpersons: Catharina Beskow and László Thurzó
08.30-08.45 Pathologic Complete Remission after Preoperative Intracavitary Radiotherapy of Cervical Cancer:
The Radiumhemmet Experience
Catharina Beskow
08.45-09.00 Tolerance and Efficacy of Preoperative Intracavitary HDR Brachytherapy in IB and IIA Cervical Cancer
Brygida Białas
09.00-09.15 Preoperative HDR Brachytherapy in the Treatment of Operable Cervical Carcinoma
– Status of the Hungarian
Multicentric Randomised Clinical Trial
Júlia Vízkeleti
09.15-09.45 New Technology for Image-guided Adaptive Brachytherapy for Gynaecological Tumours
Eric Sewsingh
09.45-10.00 Discussion
Catharina Beskow and László Thurzó
10.00-10.30 Coffee Break
ROUND-TABLE DISCUSSION II: GYNAECOLOGICAL BRACHYTHERAPY
Chairman: Primozˇ Petricˇ
10.30-11.15 Performing Successful Intracavitary Gynaecological Brachytherapy without
Access to an MRI Facility
Brygida Białas, Christian Kirisits, Jarosław Łyczek, Tibor Major, Andrzej Roszak,
László Thurzó
ORAL SESSION IV: PROFFERED PAPERS – GYNAECOLOGICAL BRACHYTHERAPY
Chairmen: László Mangel and Andrzej Roszak
11.15-11.25 Analysis of Standard Loading Patterns for Cervix BT Using MRI-Based Dosimetry
Anna Lettmayer
11.25-11.35 Use of Adjustable Applicator System for MRI-Guided BT in Cervical Cancer
Árpád Kovács
11.35-11.45 Evaluation of HDR BT Fraction Dose on Local Control and Complication in Patients with Cervical Cancer IB and IIA
Małgorzata Kraszkiewicz
11.45-11.55 Impact of Treatment Time Prolongation on Pelvic Control for Uterine Cervix Cancer – Radiobiological Modelling TCP vs. Clinical
Outcomes from EBM
Pavol Matula
12.00-13.00 Lunch
ORAL SESSION V: NEW DEVELOPEMENTS IN BT PHYSICS – INVERSE PLANNING
Chairmen: Dimos Baltas and Tibor Major
13.00-13.20 The Role of Inverse Planning in Prostate Brachytherapy
Dimos Baltas
13.20-13.35 Optimisation of Image-Based Treatment Plans for Breast HDR Implants
Tibor Major
13.35-13.50 Inverse Planning in Gynaecological Brachytherapy
Christian Kirisits
13.50-14.05 Recent and Future Developments for Brachytherapy Treatment Planning
Eric Sewsingh and Mehmet Üzümcu
14.05-14.15 Discussion
Dimos Baltas and Tibor Major
ORAL SESSION VII: PROFFERED PAPERS – BRACHYTHERAPY PHYSICS
Chairmen: Maryla Kawczyn’ska and Christian Kirisits
14.15-14.25 Irregular vs. Regular Seed Loading Pattern in Permanent Prostate Brachytherapy Planning
Georgina Fröhlich
14.25-14.35 MRI Modelling of Rectal Dosimeter Probe during MRI-Guided HDR BT for prostate: Feasibility and Initial Experiences
Antal Gergely
14.35-14.45 Development of Surface Applicator (Preliminary Results)
Jenő Pálvölgyi
14.45-15.15 Coffee Break
ROUND-TABLE DISCUSSION III: RAISING THE PROFILE OF BRACHYTHERAPY
Chairman: Bogusl/aw Maciejewski
15.15-15.30 Clinical and Economic Sunrise for Brachytherapy
Bogusław Maciejewski
15.30-17.15 Discussion:
Clinical and Economic Cost-Benefit Ratio of Brachytherapy vs. Other Modalities
(e.g. IMRT, Protons)
Driving the Cause of Brachytherapy through Better
• Evidence
• Standardisation and reproducibility (e.g. Protocols)
• Economics (e.g. Reimbursement, Investment Plans)
• Technology
• Education
• Lobbying (e.g. Healthcare Authorities, Healthcare Funds,
Professional Medical Associations beyond RT, Patients
Péter Ágoston, Dimos Baltas, Catharina Beskow, Brygida Białas, Bengt Johansson, Michel Ghilezan, Gábor Kacso, Christian Kirisits, József Lövey, Jarosław Łyczek,
Bogusław Maciejewski, Julian Malicki, Primož Petrič, Janusz Skowronek, Pavel Slampa
ORAL SESSION VIII: PROFFERED PAPERS – MISCELLANEOUS BRACHYTHERAPY (OTHER THAN BREAST, GYN AND PROSTATE)
Chairmen: Janaki Hadijev and Zoltán Takácsi-Nagy
17.15-17.25 Brachytherapy Infrastructure in Poland (2002-2008)
Wojciech Bulski
17.25-17.35 HDR BT Endobronchial in Managing Advanced Lung Cancer
– Comparison of Different Protocols
Janusz Skowronek
17.35-17.45 Palliative PDR BT in Treating Recurrent Larynx Cancer
Janusz Skowronek
17.45-17.55 HDR BT of Skin Cancer in Material of GPCC
Marek Kanikowski
17.55-18.05 Effectiveness of Yttrium-90 Colloid BT in Cystic Craniopharyngeomas
Zsuzsa Kolumbán
POSTER WALK
18.15-18.45 Poster Walk, moderated by József Lövey and Kornélia Szluha
18.45-19.15 Break
SOCIAL EVENT: AN EVENING OUT IN BUDAPEST – GUNDEL RESTAURANT (ÁLLATKERTI úT 2., BUDAPEST 1146)
19.15-23.00 Gala Dinner
Best Abstracts Awards
Party Time
Saturday 17th October 2009
ORAL SESSION IX: DEBATE ON BRACHYTHERAPY FOR LOW-RISK PROSTATE CANCER HDR VS. LDR SEEDS MONOTHERAPY
Chairmen: Bengt Johansson and Janusz Skowronek
09.00-09.15 Seeds Brachytherapy as Treatment of Choice
Péter Ágoston
09.15-09.30 HDR Brachytherapy as Treatment of Choice
Michel Ghilezan
09.30-09.45 Discussion
Péter Ágoston, Michel Ghilezan, Bengt Johansson, Janusz Skowronek
09.45-10.00 Proposal for a Central European Multicentric Randomised Clinical Trial Comparing HDR to LDR Seeds Monotherapy
Péter Ágoston, Janusz Skowronek
10.00-10.15 VIDEO PRESENTATION II
Technique and Treatment Planning of Prostate Seeds Implantation Using the Nucletron FIRST™ System
Tibor Major, Péter Ágoston
10.15-10.30 VIDEO PRESENTATION III
Technique and Treatment Planning of HDR Prostate Using Nucletron Oncentra® Prostate
Tibor Major, Péter Ágoston
10.30-11.00 New Technology for Image-Guided Adaptive Brachytherapy for Prostate Tumours
Lisette van der Vight
11.00-11.20 Discussion
Péter Ágoston, Michel Ghilezan, Bengt Johansson, Tibor Major, Janusz Skowronek,
Lisette van der Vight
11.20-11.45 Coffee break
ROUND-TABLE DISCUSSION VI: PRACTICE OF PROSTATE HDR AND SEEDS BRACHYTHERAPY
Chairman: Janusz Skowronek
11.45-12.00 Optimisation Traps of HDR to LDR Prostate Brachytherapy
– The Greater-Poland Cancer Centre Experience
Janusz Skowronek
12.00-12.30 Discussion: Learning-curve of HDR and LDR Prostate Brachytherapy
Péter Ágoston, Dimos Baltas, Michel Ghilezan, Bengt Johansson, Renata Soumarová,
Grzegorz Zwierzchowski
ORAL SESSION X: PROFFERED PAPERS – PROSTATE BRACHYTHERAPY
Chairmen: Jarosl/aw L/yczek and Péter Ágoston
12.30-12.40 Influence of Number of Needles on Prostate HDR Treatment Plan Quality
Adam Chichel
12.40-12.50 Salvage BT for Local Recurrences of Prostate Cancer Treated Earlier with RT
Marzena Gawkowska-Suwińska
12.50-13.00 Prostate HDR BT – 2 years of Treatment at the Greater-Poland Cancer Centre
Marek Kanikowski
13.00-13.10 Open MRI-Guided HDR BT for Prostate Cancer: Feasibility and Initial Experiences
Ferenc Lakosi
CLOSURE
13.15-13.30 Closing remarks
Jos Lamers and Csaba Polgár
