eISSN: 2299-0038
ISSN: 1643-8876
Menopause Review/Przegląd Menopauzalny
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SCImago Journal & Country Rank
 
4/2007
vol. 6
 
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abstract:

Comparison of classifications of hyperplastic endometrial lesions – World Health Organization and Endometrial Intraepithelial Neoplasia

Anna Sobczuk
,
Marcin Wrona

Przegląd Menopauzalny 2007; 4: 199–203
Online publish date: 2007/08/28
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Endometrial intraepithelial neoplasia (EIN) is a precursor to endometrioid endometrial adenocarcinoma characterized by monoclonal growth of mutated cells, a distinctive histopathologic appearance and 45-fold elevated cancer risk. The diagnosis of premalignant endometrial lesions remains non-standardized because the most widely used World Health Organization classification system is a poorly reproducible system, which does not specify objective architectural criteria for each category of hyperplasia and does not correspond to appropriate clinical management (under-treatment, over-treatment of lesions). The new proposed EIN diagnostic schema, based on an integrated morphological, genetic, molecular, objective histomorphometric scale (D-score) and clinical outcome studies, divides endometrial lesions into three categories: benign hyperplasia, endometrial intraepithelial neoplasia, and cancer.
keywords:

endometrial intraepithelial neoplasia (EIN), endometrioid neoplasia (EN), World Health Organization classification system, complex atypical hyperplasia (CAH), simplex atypical hyperplasia (SAH), D-score

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