Current views on molecularly targeted therapy for lung cancer – a review of literature from the last five years

Agnieszka Rybarczyk-Kasiuchnicz; Rodryg Ramlau

doi:10.5114/kitp.2018.76478

eISSN: 1897-4252
ISSN: 1731-5530

Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery

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abstract:

Review paper

Current views on molecularly targeted therapy for lung cancer – a review of literature from the last five years

Agnieszka Rybarczyk-Kasiuchnicz

,

Rodryg Ramlau

Kardiochirurgia i Torakochirurgia Polska 2018; 15 (2): 119-124

DOI: https://doi.org/10.5114/kitp.2018.76478

Online publish date: 2018/06/22

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AMA

Rybarczyk-Kasiuchnicz A, Ramlau R. Current views on molecularly targeted therapy for lung cancer – a review of literature from the last five years. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery. 2018;15(2):119-124. doi:10.5114/kitp.2018.76478.

APA

Rybarczyk-Kasiuchnicz, A.,  & Ramlau, R. (2018). Current views on molecularly targeted therapy for lung cancer – a review of literature from the last five years. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery, 15(2), 119-124. https://doi.org/10.5114/kitp.2018.76478

Chicago

Rybarczyk-Kasiuchnicz, Agnieszka,  and Rodryg Ramlau. 2018. "Current views on molecularly targeted therapy for lung cancer – a review of literature from the last five years". Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery 15 (2): 119-124. doi:10.5114/kitp.2018.76478.

Harvard

Rybarczyk-Kasiuchnicz, A.,  and Ramlau, R. (2018). Current views on molecularly targeted therapy for lung cancer – a review of literature from the last five years. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery, 15(2), pp.119-124. https://doi.org/10.5114/kitp.2018.76478

MLA

Rybarczyk-Kasiuchnicz, Agnieszka et al. "Current views on molecularly targeted therapy for lung cancer – a review of literature from the last five years." Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery, vol. 15, no. 2, 2018, pp. 119-124. doi:10.5114/kitp.2018.76478.

Vancouver

Rybarczyk-Kasiuchnicz A, Ramlau R. Current views on molecularly targeted therapy for lung cancer – a review of literature from the last five years. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery. 2018;15(2):119-124. doi:10.5114/kitp.2018.76478.

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Lung cancer is the main cause of cancer-related deaths in Poland. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are a new group of agents for non-small-cell lung cancer (NSCLC) patients. Determining the predictive value of activating mutations in the EGFR and ROS-1 genes and ALK rearrangement in non-small-cell lung cancer has enabled the identification of patients likely to achieve true clinical benefits. EGFR-TKIs may produce objective response in more than 60% of patients and prolong progression-free survival to 10 months in mutation-positive patients. No improvement of overall survival was shown in randomized trials. The era of immunotherapy implementing PD-1 and PD-L1 inhibitors has changed the face of lung cancer therapy. We aimed to review the literature on the use of EGFR-TKIs and immunotherapeutic agents for NSCLC patients.

keywords:

Current views on molecularly targeted therapy for lung cancer – a review of literature from the last five years

Agnieszka Rybarczyk-Kasiuchnicz , Rodryg Ramlau

non-small-cell lung cancer, growth factor receptor tyrosine kinase inhibitors, ALK-rearrangement, immunotherapy

Agnieszka Rybarczyk-Kasiuchnicz

,

Rodryg Ramlau