eISSN: 1897-4252
ISSN: 1731-5530
Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Reviewers Abstracting and indexing Contact Instructions for authors Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
4/2012
vol. 9
 
Share:
Share:

DZIELIMY SIĘ DOŚWIADCZENIEM
A rare cause of dyspnea and palpitations: mediastinal schwannoma

Gulacan Tekin
,
Mehmet Ozgel
,
Yusuf Kenan Tekin
,
Ali Rıza Erbay

Kardiochirurgia i Torakochirurgia Polska 2012; 9 (4): 468–470
Online publish date: 2013/01/14
Article file
- 11 Tekin.pdf  [0.71 MB]
Get citation
 
PlumX metrics:
 

Introduction

Schwannomas are nerve myelin sheath tumors and the majority of them are benign. These tumors are mostly localized at the central nervous system, extremities, neck, mediastinum and retroperitoneum but can be detected anywhere in the body. Central nervous system localization is the most common and especially the eighth cranial nerve is affected. Schwannomas are usually asymptomatic until they reach significantly large sizes and symptoms are generally dependent on the compressing adjacent structures [1-3]. We present here a very rare case with complaints of palpitations and dyspnea due to posterior mediastinal schwannoma compressing the left atrium.

Case report

A 65-year-old woman was admitted to the hospital with complaints of intermittent episodes of dyspnea, and palpitations for 2 months. She also complained of an atypical chest pain regardless of activity. Her dyspnea and palpitations worsened with time. She had a normal pulse rate and a regular rhythm, and her blood pressure was 120/70 mm Hg. No murmur or thrill was detected. Hematologic test results were within normal limits. Electrocardiogram was negative for ischemia. Chest X-ray did not reveal pulmonary vascular congestion, pulmonary edema, or cardiomegaly. Two-dimensional echocardiography showed a mass causing left atrial compression. Short axis mass diameter was 66 × 41 mm, whereas apical diameter was 50x46 mm with two-dimensional echocardiography (Fig. 1). A fat density tumor in the mediastinum compressing the left atrium was found by chest computed tomography (CT) and magnetic resonance imaging (MRI) (Fig. 2). The tumor was homogeneous, well circumscribed, with hypointense septation and was located between the left atrium and descending aorta, adjacent to the esophagus, immediately enhanced with contrast medium, rich in fat and showed no apparent invasion into surrounding tissues. The patient underwent a left posterolateral thoracotomy and the tumor was removed completely. Due to adjacent major vascular structures, resection was done carefully but the tumor mass was well circumscribed and not invading the adjacent structures. Histopathological examination of the tumor material showed that the tumor was consistent with a benign schwannoma, characterized by proliferation of spindle cells with cellular uniformity and immunohistochemically the tumor cells were positive to S-100 protein.

Discussion

Schwannomas are the most common peripheral nerve tumors [1, 4]. Neurogenic tumors represent 15-20% of primary mediastinal tumors and less than half of them are schwannomas [4]. Acoustic neuroma is the most commonly seen schwannoma and its derivation is cranial nerve VIII [5]. Schwannomas originating from the vagus nerve within the mediastinum are rare, comprising only 1.4% of intrathoracic schwannomas [6].

Schwannomas can be seen at any age although they are more frequent over forty and can be seen in men and women equally [7]. Schwann cells are glial cells of the peripheral nervous system that are located in the axon, produce myelin for the axons and serve and separate nerve cells from adjacent structures. Schwannomas originate from Schwann cells and diagnosis of these tumors is usually delayed and most often incidental due to nonspecific symptoms related to compression or invasion of adjacent structures [5]. Our case was diagnosed while searching for the cause of dyspnea, palpitations and atypical chest pain.

Histologically, schwannomas are lobulated, encapsulated, firm, fusiform-shaped cells, highly vascular, homogeneous, featuring no atypia, mitoses, increased cellularity or necrosis [7, 8]. They are rarely malign and most of these malign tumors are seen in patients with neurofibromatosis. Microscopic examination of malign schwannoma is characterized by atypia, mitoses, pleomorphism and necrosis [7]. In our case pathologic examination revealed benign schwannoma.

Radiologically these tumors have smooth margins and rarely show cystic degeneration, cavity formation, necrosis, or calcification. In preoperative evaluation, CT and MRI are useful for diagnosis of these tumors [7, 8]. Schwannomas appear in CT as a homogenous mass with heterogeneous contrast enhancement. The MRI findings of these tumors are hypointense or isointense on T1-weighted images and inhomogeneous high signal intensity on T2-weighted images [5]. In our case the tumor was first recognized in echocardiographic examination and both CT and MRI scans were performed for detection of its features.

Due to the possibility of malignancy when a schwannoma is detected, total resection is recommended for the treatment and video-assisted thoracoscopy is also a possibility. If the tumor is incompletely resected, recurrence could occur [9, 10]. In our case, the tumor was completely resected, and the patient had no postoperative complications and no complaints of dyspnea or palpitations during 6-month follow-up.

In conclusion, benign schwannomas of the vagus nerve are very rare. Patients with thoracic schwannomas could attend cardiology departments with complaints of dyspnea, palpitations and chest pain due to compression of the heart. Complete resection is a curative surgery for schwannomas.

Literature

1. Rammos KS, Rammos SK, Foroulis CN, Zaramboukas TK. Schwannoma of the vagus nerve, a rare middle mediastinal neurogenic tumor: case report. J Cardiothorac Surg 2009; 4: 68.

2. Kulkarni N, Andrews SJ, Rao V, Rajagopal KV. Case report: Benign porta hepatic schwannoma. Indian J Radiol Imaging 2009; 19: 213-215.

3. Dutta R, Kumar A, Jindal T, Tanveer N. Concurrent benign schwannoma of oesophagus and posterior mediastinum. Interact Cardiovasc Thorac Surg 2009; 9: 1032-1034.

4. Stouffer CW, Allan RW, Shillingford MS, Klodell CT. Endobronchial schwannoma presenting with bronchial obstruction. Interact Cardiovasc Thorac Surg 2010; 10: 133-134.

5. Ortigara L, Rosemberg N, Siqueira R, Neto F. Resection of a mediastinal schwannoma using video-assisted thoracoscopy. J Bras Pneumol 2006; 32: 172-175.

6. Heras F, Ramos G, Castanedo M, Cortejoso A, Duque JL, Yuste MG. Schwannoma of the intrathoracic vagus nerve. Arch Bronconeumol 1997; 33: 360-362.

7. Strollo DC, Rosado-de-Christenson ML, Jett JR. Tumors of the middle and posterior mediastinum. Chest 1997; 112: 1344-1357.

8. Jung JH, Joo KR, Chae MJ, Jang JY, Lee SG, Dong SH, Kim HJ, Kim BH, Chang YW, Lee JI, Chang R, Kim YH, Lee SM. Extrahepatic biliary schwannomas: a case report. J Korean Med Sci 2007; 22: 549-552.

9. Sakurai H, Hada M, Mitsui T, Ashizawa I. Extrathoracic neurilemoma of the lateral chest wall mimicking a subcutaneous tumor: report of a case. Ann Thorac Cardiovasc Surg 2006; 12: 133-136.

10. Yamaguchi M, Yoshino I, Fukuyama S, Osoegawa A, Kameyama T, Tagawa T, Maehara Y. Surgical treatment of neurogenic tumors of the chest. Ann Thorac Cardiovasc Surg 2004; 10: 148-151.
Copyright: © 2013 Polish Society of Cardiothoracic Surgeons (Polskie Towarzystwo KardioTorakochirurgów) and the editors of the Polish Journal of Cardio-Thoracic Surgery (Kardiochirurgia i Torakochirurgia Polska). This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.